Overexpression of Glucose Transporter-1 (GLUT-1) Predicts Poor Prognosis in Epithelial Ovarian Cancer

被引：67
|
作者：
Cho, Hanbyoul [1 ]
Lee, You Sun [1 ]
Kim, Julie [1 ,2 ]
Chung, Joon-Yong [2 ]
Kim, Jae-Hoon [1 ]
机构：
[1] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Obstet & Gynecol, Seoul 135720, South Korea
[2] NCI, Appl Mol Pathol Lab, Pathol Lab, NIH, Bethesda, MD 20892 USA
来源：
CANCER INVESTIGATION | 2013年 / 31卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
GLUT-1; Ovarian cancer; Microarray; Biomarker; Immunohistochemistry; GLUCOSE-TRANSPORTER; EXPRESSION; CARCINOMA; SURVIVAL; ANGIOGENESIS; CELLS;
D O I：
10.3109/07357907.2013.849722
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate themicroarray data, mRNA and protein level of glucose transporter-1 (GLUT-1) was examined. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. Real-time PCR and immunohistochemistry demonstrated that GLUT-1 expression was significantly increased in EOC (p=.029 and p<.001, respectively). On survival analysis, GLUT-1 overexpression (HR= 4.80, p=.027) and lymph nodemetastases (HR= 8.35, p=.016) conferred a significantly worse overall survival. In conclusion, GLUT-1 expression is remarkably upregulated in EOC and predicts a poor overall survival.
引用
收藏
页码：607 / 615
页数：9
相关论文
共 50 条
  • [41] Glucose Transporter Glut-1 Expression Correlates with Basal-Like Breast Cancer
    Hussein, Y. R.
    Bandyopadhyay, S.
    Ahmed, Q.
    Jazaerly, T.
    Albashiti, B.
    Ibrahim, M.
    Nahleh, Z.
    Sakr, W.
    Ali-Fehmi, R.
    MODERN PATHOLOGY, 2010, 23 : 52A - 52A
  • [42] Glucose Transporter Glut-1 Expression Correlates with Basal-Like Breast Cancer
    Hussein, Y. R.
    Bandyopadhyay, S.
    Ahmed, Q.
    Jazaerly, T.
    Albashiti, B.
    Ibrahim, M.
    Nahleh, Z.
    Sakr, W.
    Ali-Fehmi, R.
    LABORATORY INVESTIGATION, 2010, 90 : 52A - 52A
  • [43] Glucose and water transport by mutants at the 66 residue of the Glut-1 glucose transporter
    Ma, L
    Wang, D
    Kuang, K
    Iserovich, P
    Yang, H
    Zuniga, FA
    Pascual, JM
    De Vivo, DC
    Fischbarg, J
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 : U71 - U71
  • [44] GLUT1 glucose transporter expression in colorectal carcinoma -: A marker for poor prognosis
    Haber, RS
    Rathan, A
    Weiser, KR
    Pritsker, A
    Itzkowitz, SH
    Bodian, C
    Slater, G
    Weiss, A
    Burstein, DE
    CANCER, 1998, 83 (01) : 34 - 40
  • [45] Overexpression of GLUT1 in colorectal cancer is independently associated with poor prognosis
    Shen, Yang-Mei
    Arbman, Gunnar
    Olsson, Birgit
    Sun, Xiao-Feng
    INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, 2011, 26 (03): : 166 - 172
  • [46] CONCORDANTLY INCREASED GLUCOSE TRANSPORTER-1 (GLUT-1) GENE-EXPRESSION AND FDG-UPTAKE IN HUMAN PANCREATIC-CARCINOMA
    KORNRUMPF, D
    BUCHLER, M
    LANGHANS, J
    BEGER, HG
    RESKE, SN
    JOURNAL OF NUCLEAR MEDICINE, 1993, 34 (05) : P223 - P223
  • [47] IMMUNOCYTOCHEMICAL (ICC) LOCALIZATION OF GLUCOSE-TRANSPORTER (GLUT-1) IN RETINOBLASTOMA
    BARDENSTEIN, DS
    BENMEIR, A
    RICHEY, P
    FRIEDLAND, R
    PERRY, G
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1994, 35 (04) : 2085 - 2085
  • [48] Sprouty 1 predicts prognosis in human epithelial ovarian cancer
    Masoumi-Moghaddam, Samar
    Amini, Afshin
    Wei, Ai-Qun
    Robertson, Gregory
    Morris, David L.
    AMERICAN JOURNAL OF CANCER RESEARCH, 2015, 5 (04): : 1531 - 1541
  • [49] Glucose Transporter-1 (GLUT1)-Defect and SLC2A1- Mutations
    Rating, D.
    ZEITSCHRIFT FUR EPILEPTOLOGIE, 2013, 26 (02): : 103 - 104
  • [50] Glucose Transporter 1 (GLUT-1) expression and cellular localization in early colorectal neoplasia
    Bakheit, S
    Dolan, J
    O'Sullivan, J
    Keating, G
    Gorman, J
    Mulcahy, H
    Hyland, J
    O'Donoghue, D
    Sheahan, K
    LABORATORY INVESTIGATION, 2005, 85 : 97A - 98A
12345