Overexpression of Glucose Transporter-1 (GLUT-1) Predicts Poor Prognosis in Epithelial Ovarian Cancer

被引：67

作者：

Cho, Hanbyoul ^{[1
]}

Lee, You Sun ^{[1
]}

Kim, Julie ^{[1
,2
]}

Chung, Joon-Yong ^{[2
]}

Kim, Jae-Hoon ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Obstet & Gynecol, Seoul 135720, South Korea

[2] NCI, Appl Mol Pathol Lab, Pathol Lab, NIH, Bethesda, MD 20892 USA

来源：

CANCER INVESTIGATION | 2013年 / 31卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

GLUT-1; Ovarian cancer; Microarray; Biomarker; Immunohistochemistry; GLUCOSE-TRANSPORTER; EXPRESSION; CARCINOMA; SURVIVAL; ANGIOGENESIS; CELLS;

D O I：

10.3109/07357907.2013.849722

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate themicroarray data, mRNA and protein level of glucose transporter-1 (GLUT-1) was examined. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. Real-time PCR and immunohistochemistry demonstrated that GLUT-1 expression was significantly increased in EOC (p=.029 and p<.001, respectively). On survival analysis, GLUT-1 overexpression (HR= 4.80, p=.027) and lymph nodemetastases (HR= 8.35, p=.016) conferred a significantly worse overall survival. In conclusion, GLUT-1 expression is remarkably upregulated in EOC and predicts a poor overall survival.

引用

页码：607 / 615

页数：9

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