Overexpression of Glucose Transporter-1 (GLUT-1) Predicts Poor Prognosis in Epithelial Ovarian Cancer

被引：67
|
作者：
Cho, Hanbyoul [1 ]
Lee, You Sun [1 ]
Kim, Julie [1 ,2 ]
Chung, Joon-Yong [2 ]
Kim, Jae-Hoon [1 ]
机构：
[1] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Obstet & Gynecol, Seoul 135720, South Korea
[2] NCI, Appl Mol Pathol Lab, Pathol Lab, NIH, Bethesda, MD 20892 USA
来源：
CANCER INVESTIGATION | 2013年 / 31卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
GLUT-1; Ovarian cancer; Microarray; Biomarker; Immunohistochemistry; GLUCOSE-TRANSPORTER; EXPRESSION; CARCINOMA; SURVIVAL; ANGIOGENESIS; CELLS;
D O I：
10.3109/07357907.2013.849722
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate themicroarray data, mRNA and protein level of glucose transporter-1 (GLUT-1) was examined. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. Real-time PCR and immunohistochemistry demonstrated that GLUT-1 expression was significantly increased in EOC (p=.029 and p<.001, respectively). On survival analysis, GLUT-1 overexpression (HR= 4.80, p=.027) and lymph nodemetastases (HR= 8.35, p=.016) conferred a significantly worse overall survival. In conclusion, GLUT-1 expression is remarkably upregulated in EOC and predicts a poor overall survival.
引用
收藏
页码：607 / 615
页数：9
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