Association of an intronic polymorphism in the midkine (MK) gene with human sporadic colorectal cancer

被引：10

作者：

Ahmed, KM

Shitara, Y

Takenoshita, S

Kuwano, H

Saruhashi, S

Shinozawa, T ^{[1
]}

机构：

[1] Gunma Univ, Fac Engn, Dept Biol & Chem Engn, Kiryu, Gumma 3768515, Japan

[2] Gunma Univ, Sch Med, Dept Surg 1, Maebashi, Gumma 3718511, Japan

[3] Fukushima Med Univ, Dept Surg 2, Fukushima 9601295, Japan

来源：

CANCER LETTERS | 2002年 / 180卷 / 02期

关键词：

cancer; colorectal; midkine; polymorphism; intron;

D O I：

10.1016/S0304-3835(02)00040-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Midkine (MK) is a heparin-binding growth factor specified by a retinoic acid responsive gene. It plays important roles in development and carcinogenesis. The MK gene is located on chromosome 11q11.2 in humans. A heterozygous G to T transition at the 62nd base in intron 3 of this gene has been identified in sporadic colorectal and gastric cancers (Int. J. Mol. Med. 6 (2000) 28 1). To clarify whether this polymorphism is associated with a cancer risk, a case-control study was conducted. We examined 98 colorectal, 60 gastric, 59 esophagus, 32 lung and 37 breast cancer tissue specimens and their corresponding non-neoplastic tissues. Also, 86 unaffected control specimens were examined. The G/T genotype frequency in colorectal cancers was higher than that in normal samples (11,2 versus 2.3%; P = 0.017). Therefore, this genotype could represent a risk factor for tumorigenesis in the colon and rectum of Japanese. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：159 / 163

页数：5

共 27 条

[1] GROWTH-FACTORS AND CANCER [J].