Serum microRNA-21 levels are related to tumor size in gastric cancer patients but cannot predict prognosis

被引:44
作者
Song, Jianning [1 ]
Bai, Zhigang [1 ]
Zhang, Jun [1 ]
Meng, Hua [1 ]
Cai, Jun [1 ]
Deng, Wei [1 ]
Bi, Jintao [1 ]
Ma, Xuemei [1 ]
Zhang, Zhongtao [1 ]
机构
[1] Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China
关键词
biomarker; microRNA-21; stomach neoplasma; prognosis; CIRCULATING MICRORNAS; EXPRESSION; MIR-21; PLASMA; INVASION; PROMOTES; PROLIFERATION; BIOMARKERS; CARCINOMAS; CELLS;
D O I
10.3892/ol.2013.1626
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In patients with gastric cancer (GC), circulating microRNA-21 (miR-21) is overexpressed and may serve as a diagnostic biomarker. In the present study, it was hypothesized that the serum miR-21 expression levels were associated with prognosis in the patients with GC. The expression levels of serum miR-21 were measured using quantitative polymerase chain reaction (qPCR) assays in 103 GC patients. Survival and Cox proportional-hazards regression analyses were performed to determine the correlation between serum miR-21 expression levels and prognosis in the patients. The correlation between the serum miR-21 levels and the clinicopathological factors of the patients was also analyzed. Survival curves were not significantly different between the groups exhibiting high and low levels of serum miR-21 expression. High levels of miR-21 in the serum were associated with an increased tumor size and an advanced pT stage. These findings suggest that serum miR-21 could be exploited as a practical biomarker for monitoring tumor burden in patients with GC.
引用
收藏
页码:1733 / 1737
页数:5
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