Are corticosteroids effective for prevention of scar formation after second-degree skin burn?

被引：12

作者：

Taheri, Arash ^{[1
]}

Mansoori, Parisa ^{[2
]}

Al-Dabagh, Amir ^{[1
]}

Feldman, Steven R. ^{[1
,2
,3
]}

机构：

[1] Wake Forest Sch Med, Dept Dermatol, Ctr Dermatol Res, Winston Salem, NC 27104 USA

[2] Wake Forest Sch Med, Dept Pathol, Winston Salem, NC 27104 USA

[3] Wake Forest Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27104 USA

来源：

JOURNAL OF DERMATOLOGICAL TREATMENT | 2014年 / 25卷 / 04期

关键词：

glucocorticoid; inflammation; keloid; steroid; ulcer; POSTOPERATIVE STEROID INJECTIONS; HYPERTROPHIC SCARS; TRIAMCINOLONE ACETONIDE; KELOIDS; MANAGEMENT; EXCISION; PATHOPHYSIOLOGY; RECURRENCE; EXPRESSION; THERAPY;

D O I：

10.3109/09546634.2013.806768

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Superficial second-degree skin burns only need re-epithelialization to heal without a scar. After re-epithelialization, inflammation in the dermis contributes to changes in skin architecture and scarring. Suppression of inflammation and fibroblast activation immediately after re-epithelialization may prevent scar formation. Corticosteroids are the mainstay of treatment for keloids and hypertrophic scars. Objective: To assess the available data on use of corticosteroids for prevention of scars. Methods: A review of literature was performed seeking clinical trials using corticosteroids for prevention of scars. Results: Corticosteroids have been used to prevent recurrence after keloid or hypertrophic scar excision with variable success. We did not find any report involving the clinical use of corticosteroids for the prevention of scar formation in other settings, including after skin burns. Conclusion: Theoretically, topical corticosteroids can suppress inflammation and fibroblast activation after skin burn, decreasing the incidence of scar formation. However, there is no study evaluating this hypothesis.

引用

页码：360 / 362

页数：3

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