Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas

被引：8
作者：
Cunha, Karin S. [1 ]
Caruso, Anabela C. [2 ]
Faria, Paulo A. [3 ]
Da Silva, Licinio E. [4 ]
Da Fonseca, Eliene C. [1 ]
Geller, Mauro [5 ]
De Moura-Neto, Rodrigo S. [6 ]
Lopes, Vania S. [1 ]
机构：
[1] Univ Fed Fluminense, Hosp Univ Antonio Pedro, Programa Posgrad Patol, BR-24033090 Niteroi, RJ, Brazil
[2] Inst Nacl Traumatol & Ortopedia, Serv Anat Patol, BR-20940070 Rio De Janeiro, RJ, Brazil
[3] Inst Nacl Canc, Div Pathol, BR-20220400 Rio De Janeiro, RJ, Brazil
[4] Univ Fed Fluminense, Dept Estat, Inst Matemat & Estat, BR-24020140 Niteroi, RI, Brazil
[5] Ctr Univ Serra Orgaos UNIFESO, Dept Microbiol & Immunol, BR-25964004 Teresopolis, RJ, Brazil
[6] Univ Fed Rio de Janeiro, Inst Biol, BR-21941902 Rio De Janeiro, Brazil
来源：
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2013年 / 85卷 / 04期
关键词：
apoptosis regulatory proteins; malignant peripheral nervous sheath tumors; neurofibroma; Neurofibromatosis; 1; GROWTH-HORMONE RECEPTOR; SOFT-TISSUE SARCOMAS; CELL LUNG-CANCER; IMMUNOHISTOCHEMICAL ANALYSIS; BREAST-CANCER; PROGNOSTIC VALUE; PROTEIN EXPRESSION; SCHWANN-CELLS; P53; PROTEIN; IN-VIVO;
D O I：
10.1590/0001-3765201320120026
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
AIMS: To study the expression of Bcl-2, Bcl-x, as well the presence of cleaved caspase-3 in neurofibromas and malignant peripheral nerve sheath tumors. The expression of Bcl-2 and Bcl-x and the presence of cleaved caspase 3 were compared to clinicopathological features of malignant peripheral nerve sheath tumors and their impact on survival rates were also investigated. MATERIALS AND METHODS: The evaluation of Bcl-2, Bcl-x and cleaved caspase-3 was performed by immunohistochemistry using tissue microarrays in 28 malignant peripheral nerve sheath tumors and 38 neurofibromas. Immunoquantification was performed by computerized digital image analysis. CONCLUSIONS: Apoptosis is altered in neurofibromas and mainly in malignant peripheral nerve sheath tumors. High levels of cleaved caspase-3 are more common in tumors with more aggressive histological features and it is associated with lower disease free survival of patients with malignant peripheral nerve sheath tumors.
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页码：1497 / 1511
页数：15
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