Dysregulation of Angiopoietin 1 and 2 in Escherichia coli O157:H7 Infection and the Hemolytic-Uremic Syndrome

被引：27
作者：
Page, Andrea V. [1 ,2 ]
Tarr, Phillip I. [3 ,4 ]
Watkins, Sandra L. [5 ,6 ]
Rajwans, Nimerta [2 ]
Petruzziello-Pellegrini, Tania N. [8 ,9 ,10 ]
Marsden, Philip A. [8 ,9 ,10 ,11 ,12 ]
Kain, Kevin C. [1 ,2 ]
Liles, W. Conrad [1 ,2 ,7 ]
机构：
[1] Univ Toronto, Mt Sinai Hosp, Univ Hlth Network, Div Infect Dis, Toronto, ON M5S 1A1, Canada
[2] Univ Toronto, Mt Sinai Hosp, Univ Hlth Network, Dept Med,Sandra A Rotman Lab Global Hlth, Toronto, ON M5S 1A1, Canada
[3] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[5] Seattle Childrens Hosp, Div Nephrol, Seattle, WA USA
[6] Univ Washington, Dept Pediat, Sch Med, Seattle, WA 98195 USA
[7] Univ Washington, Sch Med, Dept Med, Div Allergy & Infect Dis, Seattle, WA 98195 USA
[8] Univ Toronto, St Michaels Hosp, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A1, Canada
[9] Univ Toronto, St Michaels Hosp, Keenan Res Ctr, Toronto, ON M5S 1A1, Canada
[10] Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON M5S 1A1, Canada
[11] Univ Toronto, St Michaels Hosp, Div Renal, Toronto, ON M5S 1A1, Canada
[12] Univ Toronto, St Michaels Hosp, Dept Med, Toronto, ON M5S 1A1, Canada
来源：
JOURNAL OF INFECTIOUS DISEASES | 2013年 / 208卷 / 06期
基金：
加拿大健康研究院; 美国国家卫生研究院;
关键词：
angiopoietin; 1; 2; E. coli O157:H7; hemolytic-uremic syndrome; endothelial dysfunction; CEREBRAL MALARIA; MORTALITY; CHILDREN;
D O I：
10.1093/infdis/jit268
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Escherichia coli O157:H7-associated hemolytic-uremic syndrome (HUS) is characterized by profound prothrombotic abnormalities. Endothelial dysfunction, manifested as dysregulation of angiopoietins 1 and 2 (Ang-1/2), could underlie HUS pathophysiology. We measured Ang-1/2 in 77 children with E. coli O157:117 infection. Ang-1, Ang-2, and the Ang-2/Ang-1 ratio were significantly different in HUS vs the pre-HUS phase of illness or uncomplicated infection. Angiopoietin dysregulation preceded HUS and worsened as HUS developed. In vitro exposure of human microvascular endothelial cells to Shiga toxin recapitulated the in vivo observations. Angiopoietin regulation is profoundly affected before and during HUS, reflecting that subclinical endothelial dysfunction precedes overt microangiopathy.
引用
收藏
页码：929 / 933
页数：5
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