Dietary and Lifestyle Oxidative Balance Scores and Incident Colorectal Cancer Risk among Older Women; the Iowa Women's Health Study

被引:6
作者
Mao, Ziling [1 ]
Prizment, Anna E. [2 ,3 ]
Lazovich, DeAnn [3 ,4 ]
Gibbs, David C. [1 ]
Bostick, Roberd M. [1 ,5 ]
机构
[1] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, 1518 Clifton Rd NE 1518-002-3BB, Atlanta, GA 30322 USA
[2] Univ Minnesota, Div Hematol Oncol & Transplantat, Med Sch, Minneapolis, MN USA
[3] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA
[4] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA
[5] Emory Univ, Winship Canc Inst, Atlanta, GA USA
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2021年 / 73卷 / 11-12期
基金
美国国家卫生研究院;
关键词
FOOD-FREQUENCY QUESTIONNAIRE; IN-VIVO; PHYSICAL-ACTIVITY; COLON-CANCER; FECAL WATER; DNA-DAMAGE; BILE-ACIDS; STRESS; ANTIOXIDANTS; INFLAMMATION;
D O I
10.1080/01635581.2020.1821904
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Basic science literature strongly supports a role of oxidative stress in colorectal cancer (CRC) etiology, but in epidemiologic studies, associations of most individual exposures with CRC have been weak or inconsistent. However, recent epidemiologic evidence suggests that the collective effects of these exposures on oxidative balance and CRC risk may be substantial. Methods Using food frequency and lifestyle questionnaire data from the prospective Iowa Women's Health Study (1986-2012), we investigated associations of 11-component dietary and 4-component lifestyle oxidative balance scores (OBS) with incident CRC using multivariable Cox proportional hazards regression. Results Of the 33,736 cancer-free women aged 55-69 years at baseline, 1,632 developed CRC during follow-up. Among participants in the highest relative to the lowest dietary and lifestyle OBS quintiles (higher anti-oxidant relative to pro-oxidant exposures), the adjusted hazard ratios (HRs) and their 95% confidence intervals (CI) were, respectively, 0.77 (0.63, 0.94) (P-trend=0.02) and 0.61 (0.52, 0.71) (P-trend<0.0001). Among those in the highest relative to the lowest joint lifestyle/dietary OBS quintile, the HR was 0.45 (95% CI 0.26, 0.77). Conclusions Our findings suggest that a predominance of antioxidant over pro-oxidant dietary and lifestyle exposures-separately and especially jointly-may be inversely associated with CRC risk among older women.
引用
收藏
页码:2323 / 2335
页数:13
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