Oligonucleotide conjugates of Nile Red

被引：6

作者：

Prokhorenko, IA ^{[1
]}

Dioubankova, NN ^{[1
]}

Korshun, VA ^{[1
]}

机构：

[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2004年 / 23卷 / 1-2期

基金：

俄罗斯基础研究基金会;

关键词：

modified oligonucleotides; Nile Red; interaction with ds DNA;

D O I：

10.1081/NCN-120028344

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oligonucleotides containing long chain amine on uridine-2'-carbamate have been covalently modified with Nile Red, a hydrophobic long wavelength fluorescent benzophenoxazine dye. The fluorescence of the dye is quenched in oligonucleotide conjugates. Thermal denaturation studies show considerable interactions of Nile Red with DNA-DNA duplexes.

引用

页码：509 / 520

页数：12

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