Antibiotic inhibitors of organellar protein synthesis in Plasmodium falciparum

被引：63

作者：

Clough, B ^{[1
]}

Rangachari, K ^{[1
]}

Strath, M ^{[1
]}

Preiser, PR ^{[1
]}

Wilson, RJMI ^{[1
]}

机构：

[1] Natl Inst Med Res, London NW7 1AA, England

来源：

PROTIST | 1999年 / 150卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1434-4610(99)70021-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Elongation factor Tu (EF-Tu) is encoded by the tuf gene of the plastid organelle of the malaria parasite Plasmodium falciparum. A range of structurally unrelated inhibitors of this GTP-dependent translation factor was shown to have antimalarial activity in blood cultures. The most active was the cyclic-thiazolyl peptide amythiamicin A with an IC50 = 0.01 mu M. Demonstrable complexes were formed in vitro between a recombinant version of P. falciparum EF-Tu(pl) and inhibitors that bind to different sites on EF-Tu; these included the antibiotics kirromycin, GE2270A and enacyloxin IIa.

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页码：189 / 195

页数：7

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