Extremely low frequency magnetic field induces hyperalgesia in mice modulated by nitric oxide synthesis

被引:33
作者
Jeong, JH
Chan, C
Choi, HJ
Park, ES
Sohn, UD
机构
[1] Chung Ang Univ, Dept Pharmacol, Coll Pharm, Seoul 156756, South Korea
[2] Chung Ang Univ, Dept Pathol, Sch Med, Seoul 156756, South Korea
[3] Chung Ang Univ, Dept Pharmacol, Sch Med, Seoul 156756, South Korea
关键词
extremely low frequency magnetic field; nitric oxide; hyperalgesia;
D O I
10.1016/j.lfs.2005.07.006
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We investigated an effect of extremely low frequency magnetic field (ELF-MF, 60 Hz) oil hyperalgesia using hot plate test. The level of nitric oxide (NO) and the expression of nitric oxide synthase (NOS) were measured to determine if ELF-MF is engaged in NO mediated pain mechanism. Additionally, the involvement of Ca2+-dependent NO pathway in ELF-MF induced hyperalgesia was evaluated by blocking Ca2+ sources with NMDA receptor antagonist and Ca2+ channel blocker. The exposure of mice to ELF-MF lowered pain threshold and elevated NO synthesis in brain and spinal cord. An NOS inhibitor blocked these effects of ELF-MF with attenuating the reduction of pain threshold and the rise of NO level in brain and spine by the exposure of ELF-MF. The hyperalgesic effects of ELF-MF were also blocked by a Ca2+ channel blocker, nimodipine, but not by a NMDA receptor antagonist, MK-801. The expression of Ca2+-dependent nNOS and eNOS and Ca2+-independent iNOS were not changed by ELF-MF. These results indicated that the exposure of ELF-MF might cause Ca2+-dependent NOS activation, which then induces hyperalgesia with the increase in NO synthesis. In conclusion, ELF-MF may produce hyperalgesia by modulating NO synthesis via Ca2+-dependent NOS. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:1407 / 1412
页数:6
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