Porous hyaluronic acid/sodium alginate composite scaffolds for human adipose-derived stem cells delivery

被引：18

作者：

Son, Yun-Jeong ^{[1
,2
]}

Yoon, In-Soo ^{[3
,4
]}

Sung, Jong-Hyuk ^{[5
]}

Cho, Hyun-Jong ^{[6
]}

Chung, Suk-Jae ^{[1
,2
]}

Shim, Chang-Koo ^{[1
,2
]}

Kim, Dae-Duk ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

[3] Mokpo Natl Univ, Coll Pharm, Jeonnam 534729, South Korea

[4] Mokpo Natl Univ, Nat Med Res Inst, Jeonnam 534729, South Korea

[5] CHA Univ, Dept Appl Biosci, Seoul 135081, South Korea

[6] Kangwon Natl Univ, Coll Pharm, Chunchon 200701, South Korea

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2013年 / 61卷

基金：

新加坡国家研究基金会;

关键词：

Chondrogenic differentiation; Human adipose-derived stem cells; Hyaluronic acid; Interpenetrating polymeric network; Sodium alginate; INTERPENETRATING POLYMER NETWORKS; ARTICULAR-CARTILAGE REPAIR; CHONDROGENIC DIFFERENTIATION; ACID SCAFFOLD; BONE-MARROW; TISSUE; CHONDROCYTES; BEADS; TRANSPLANTATION; PHENOTYPE;

D O I：

10.1016/j.ijbiomac.2013.06.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study is to evaluate the feasibility of hyaluronic acid/sodium alginate (HA/SA) scaffold-based interpenetrating polymeric network (IPN) for the proliferation and chondrogenic differentiation of the human adipose-derived stem cells (hADSCs). The hADSCs cultured in HA/SA IPN scaffold exhibited enhanced cell adhesion and proliferation compared to the HA scaffold. Superior chondrogenic differentiation of hADSCs in HA/SA IPN scaffold, compared to HA-based scaffold, was confirmed by measuring expression levels of chondrogenic markers. These results suggested that HA/SA IPN scaffold could provide a desirable environment for the cell adhesion, proliferation and chondrogenic differentiation of hADSCs. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：175 / 181

页数：7

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