A Phase 2A study of the Histone-Deacetylase Inhibitor ITF2357 in Patients with Jak2V617F Positive Chronic Myeloproliferative Neoplasms

被引:0
|
作者
Rambaldi, Alessandro [1 ]
Dellacasa, Chiara Maria [2 ]
Salmoiraghi, Silvia [2 ]
Spinelli, Orietta [2 ]
Ferrari, Maria Luisa [2 ]
Gattoni, Elisabetta [3 ]
Guglielmelli, Paola [4 ]
Vannucchi, Alessandro M. [4 ]
Barosi, Giovanni [5 ]
Barbui, Tiziano [2 ]
机构
[1] Hosp Santa Creu & Sant Pau, Clin Hematol Div, Barcelona, Spain
[2] Osped Riuniti Bergamo, USC Hematol, I-24100 Bergamo, Italy
[3] Policlin San Matteo, Fdn IRCCS, Lab Epidemiol Clin, I-27100 Pavia, Italy
[4] Univ Florence, Florence, Italy
[5] Ist Policlin San Matteo, Clin Epidemiol Unit, Ctr Study Myelofibrosis, Pavia, Italy
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:44 / 45
页数:2
相关论文
共 50 条
  • [1] A pilot study of the Histone-Deacetylase inhibitor Givinostat in patients with JAK2V617F positive chronic myeloproliferative neoplasms
    Rambaldi, Alessandro
    Dellacasa, Chiara Maria
    Finazzi, Guido
    Carobbio, Alessandra
    Ferrari, Maria Luisa
    Guglielmelli, Paola
    Gattoni, Elisabetta
    Salmoiraghi, Silvia
    Finazzi, Maria Chiara
    Di Tollo, Silvia
    D'Urzo, Carmine
    Vannucchi, Alessandro M.
    Barosi, Giovanni
    Barbui, Tiziano
    BRITISH JOURNAL OF HAEMATOLOGY, 2010, 150 (04) : 446 - 455
  • [2] The histone deacetylase inhibitor ITF2357 selectively targets cells bearing mutated JAK2V617F
    V Guerini
    V Barbui
    O Spinelli
    A Salvi
    C Dellacasa
    A Carobbio
    M Introna
    T Barbui
    J Golay
    A Rambaldi
    Leukemia, 2008, 22 : 740 - 747
  • [3] The histone deacetylase inhibitor ITF2357 selectively targets cells bearing mutated JAK2V617F
    Guerini, V.
    Barbui, V.
    Spinelli, O.
    Salvi, A.
    Dellacasa, C.
    Carobbio, A.
    Introna, M.
    Barbui, T.
    Golay, J.
    Rambaldi, A.
    LEUKEMIA, 2008, 22 (04) : 740 - 747
  • [4] Selective targeting of the JAK2V617F mutation in polycythemia vera and essential thrombocythemia by ITF2357, a novel histone deacetylase inhibitor
    Guerini, Vittoria
    Barbui, Valentina
    Spinelli, Orietta
    Salvi, Anna
    Dellacasa, Chiara
    Introna, Martino
    Barbui, Tiziano
    Golay, Josee
    Rambaldi, Alessandro
    BLOOD, 2007, 110 (11) : 170A - 171A
  • [5] The HDAC INHIBITOR ITF2357 MODULATES KEY HEMATOPOIETIC GENES in JAK2V617F CELLS From MYELOPROLIFERATIVE Neoplasm PATIENTS
    Amaru, Ariel
    Todoerti, Katia
    Pellicioli, Anna
    Donadoni, Luca
    Tuana, Giacomo
    Pedrini, Olga
    Finazzi, Guido
    Neri, Antonino
    Fossati, Gianluca
    Rambaldi, Alessandro
    Introna, Martino
    Lombardi, Luigia
    Golay, Josee
    BLOOD, 2010, 116 (21) : 348 - 349
  • [6] Potent inhibition of EEC colony formation in JAK2V617F PV and ET by low doses of ITF2357, a new histone deacetylase inhibitor.
    Guerini, Vittoria
    Spinelli, Orietta
    Salvi, Anna
    Finazzi, Guido
    Barbui, Tiziano
    Introna, Martino
    Golay, Josee
    Rambaldi, Alessandro
    BLOOD, 2006, 108 (11) : 764A - 764A
  • [7] Potent and selective inhibition of EEC colony formation in JAK2V617F polycythemia vera and thrombocythemia by low doses of ITF2357, a new histone deacetylase inhibitor
    Guerini, V.
    Spinelli, O.
    Salvi, A.
    Finazzi, G.
    Barbui, T.
    Introna, M.
    Golay, J.
    Rambaldi, A.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 : 89 - 89
  • [8] Phase II study of the histone-deacetylase inhibitor ITF2357 in relapsed/refractory Hodgkin's lymphoma patients
    Viviani, S.
    Bonfante, V.
    Fasola, C.
    Valagussa, P.
    Gianni, A. M.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [9] Potent and selective inhibition of EEC colony formation in JAK2V617F polycythemia vera and thrombocythemia by low doses of ITF2357, a new histone deacetylase inhibitor
    Guerini, V
    Spinelli, O.
    Salvi, A.
    Finazzi, G.
    Barbui, T.
    Introna, M.
    Golay, J.
    Rambaldi, A.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 : 123 - 123
  • [10] JAK2V617F allele burden in patients with myeloproliferative neoplasms
    Salem H. Alshemmari
    Reshmi Rajaan
    Reem Ameen
    Mohammad A. Al-Drees
    Marwa R. Almosailleakh
    Annals of Hematology, 2014, 93 : 791 - 796