Regioselective Synthesis of Some New Pyrazolo[1,5-a]pyrimidines, Pyrazolo[1,5-a]quinazoline and Pyrimido[4,5:3,4]pyrazolo[1,5-a] pyrimidines Containing Thiazole Moiety

被引：5
作者：
Bondock, Samir [1 ,2 ]
Tarhoni, Abd El-Gaber [1 ]
Fadda, Ahmed A. [1 ]
机构：
[1] Mansoura Univ, Fac Sci, Dept Chem, ET-35516 Mansoura, Egypt
[2] King Khalid Univ, Fac Sci, Dept Chem, Abha 9004, Saudi Arabia
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 52卷 / 06期
关键词：
ANTAGONISTS; POTENT; DERIVATIVES; ROUTES; SAR;
D O I：
10.1002/jhet.2278
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A regioselective synthesis of novel pyrazolo[1,5-a]pyrimidines, pyrazolo[1,5-a]quinazoline and pyrimido[4,5:3,4]pyrazolo[1,5-a]pyrimidines incorporating a thiazole moiety was described via the reactions of the versatile, readily accessible 5-amino-3-(phenylamino)-N-(4-phenylthiazol-2-yl)-1H-pyrazole-4-carboxamide 3 with appropriate 1,3-biselectrophilic reagents namely, -diketones, enaminones, and ,-unsaturated cyclic ketone. The newly synthesized compounds were elucidated by elemental analysis, spectral data, and alternative synthetic route whenever possible.
引用
收藏
页码：1792 / 1799
页数：8
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