Drug addiction is associated with leukocyte telomere length

被引：46

作者：

Yang, Zhaoyang ^{[1
]}

Ye, Junyi ^{[1
]}

Li, Candong ^{[2
]}

Zhou, Daizhan ^{[5
]}

Shen, Qin ^{[3
]}

Wu, Ji ^{[5
]}

Cao, Lan ^{[1
]}

Wang, Ting ^{[3
]}

Cui, Daxiang ^{[5
,7
]}

He, Shigang ^{[5
,8
]}

Qi, Guoyang ^{[4
]}

He, Lin ^{[1
,5
,6
]}

Liu, Yun ^{[1
,9
]}

机构：

[1] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China

[2] Fujian Univ Tradit Chinese Med, Fuzhou, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China

[4] Wuxi Mental Hlth Ctr, Wuxi, Jiangsu, Peoples R China

[5] Shanghai Jiao Tong Univ, Minist Educ, Key Lab Genet Dev & Neuropsychiat Disorders, Bio X Inst, Shanghai 200030, Peoples R China

[6] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China

[7] Shanghai Jiao Tong Univ, Res Inst Micro Nano Sci & Technol, Shanghai 200240, Peoples R China

[8] Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200240, Peoples R China

[9] Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Key Lab Mol Med,Minist Educ, Shanghai 200032, Peoples R China

来源：

SCIENTIFIC REPORTS | 2013年 / 3卷

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE STRESS; LIFE STRESS; HEROIN; DISEASE; CANCER; COCAINE; HEALTH; RISK; LUNG; SNUS;

D O I：

10.1038/srep01542

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Telomeres are protective chromosomal structures that play a key role in preserving genomic stability. Telomere length is known to be associated with ageing and age-related diseases. To study the impairment of telomeres induced by drug abuse, we conducted an association study in the Chinese Han population. Multivariate linear regression analyses were performed to evaluate the correlation of leukocyte telomere length (LTL) with addiction control status adjusted for age and gender. The results showed that drug abusers exhibited significantly shorter LTLs than controls (P = 1.32-206). The time before relapse also presented an inverse correlation with LTL (P = 0.02). Drug abusers who had used heroin and diazepam displayed a shorter LTL than those taking other drugs (P = 0.018 and P = 0.009, respectively). Drug abusers who had ingested drugs via snuff exhibited longer LTLs than those using other methods (P = 0.02). These observations may offer a partial explanation for the effects of drug addiction on health.

引用

页数：6

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