Can Mean Platelet Volume be a New Risk Factor in Portal Venous Thrombosis?

被引:12
作者
Aliosmanoglu, Ibrahim [1 ]
Gul, Mesut [1 ]
Oguz, Abdullah [1 ]
Basol, Omer [1 ]
Uslukaya, Omer [1 ]
Keles, Celalettin [1 ]
机构
[1] Dicle Univ, Dept Gen Surg, TR-21280 Diyarbakir, Turkey
关键词
portal venous thrombosis; mean platelet volume; etiology; VEIN-THROMBOSIS; ACTIVATION;
D O I
10.1177/1076029612464903
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The aim of this study was to discuss the possibility of mean platelet volume (MPV) being a new risk factor in the etiology of portal venous thrombosis (PVT). Methods: Study participants were categorized into 2 different groups: group I, control group (n = 35) and group II, PVT group (n = 34). Demographic data and MPV values were recorded retrospectively. Results: No differences were determined between the 2 groups regarding hypertension, diabetes mellitus, and smoking (P > .05). The average hemoglobin levels were 10.8 +/- 2.1 in group II and 14.0 +/- 1.7 in group I (P < .001). Although the MPV levels of group II patients were 8.2 +/- 0.52, the average level in group I was determined as 7.8 +/- 0.62 (P = .012). In the performed receiver-operating characteristic (ROC) analysis, the cutoff value for patients with PVT for MPV was determined as 7.9 (area under curve: 0.674), sensitivity as 70.6%, and specificity as 65.7% (P = .013). Conclusion: The current study shows that MPV is significantly higher in patients with PVT than in the control group.
引用
收藏
页码:433 / 436
页数:4
相关论文
共 22 条
[1]   Platelet size: Measurement, physiology and vascular disease [J].
Bath, PMW ;
Butterworth, RJ .
BLOOD COAGULATION & FIBRINOLYSIS, 1996, 7 (02) :157-161
[2]   Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey, 1999-2004 [J].
Berger, Jeffrey S. ;
Eraso, Luis H. ;
Xie, Dawei ;
Sha, Daohang ;
Mohler, Emile R., III .
ATHEROSCLEROSIS, 2010, 213 (02) :586-591
[3]   Mean platelet volume is a risk factor for venous thromboembolism: the Troms⊘ study [J].
Braekkan, S. K. ;
Mathiesen, E. B. ;
Njolstad, I. ;
Wilsgaard, T. ;
Stormer, J. ;
Hansen, J. B. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2010, 8 (01) :157-162
[4]   The mean platelet volume in patients with obesity [J].
Coban, E ;
Ozdogan, M ;
Yazicioglu, G ;
Akcit, F .
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2005, 59 (08) :981-982
[5]   Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions [J].
Coppinger, JA ;
Cagney, G ;
Toomey, S ;
Kislinger, T ;
Belton, O ;
McRedmond, JP ;
Cahill, DJ ;
Emili, A ;
Fitzgerald, DJ ;
Maguire, PB .
BLOOD, 2004, 103 (06) :2096-2104
[6]   Screening tests for thrombophilic patients: Which tests, for which patient, by whom, when, and why? [J].
De Moerloose, P ;
Bounameaux, HR ;
Mannucci, PM .
SEMINARS IN THROMBOSIS AND HEMOSTASIS, 1998, 24 (04) :321-327
[7]   SMALL-INTESTINAL STRICTURE COMPLICATING SUPERIOR MESENTERIC VEIN-THROMBOSIS - A STUDY OF 3 CASES [J].
EUGENE, C ;
VALLA, D ;
WESENFELDER, L ;
FINGERHUT, A ;
BERGUE, A ;
MERRER, J ;
FELSENHELD, C ;
MOUNDJI, A ;
ETIENNE, JC .
GUT, 1995, 37 (02) :292-295
[8]   Platelets in inflammation and atherogenesis [J].
Gawaz, M ;
Langer, H ;
May, AE .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (12) :3378-3384
[9]  
GRENDELL JH, 1982, GASTROENTEROLOGY, V82, P358
[10]   Mean Platelet Volume Is Increased in Patients With Deep Vein Thrombosis [J].
Gulcan, Mehmet ;
Varol, Ercan ;
Etli, Mustafa ;
Aksoy, Fatih ;
Kayan, Mustafa .
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2012, 18 (04) :427-430