Fibulin-5 expression is decreased in women with anterior vaginal wall prolapse

被引：26
作者：
Takacs, Peter [1 ]
Nassiri, Mehdi [2 ]
Viciana, Anita [2 ]
Candiotti, Keith [3 ]
Fornoni, Alessia [4 ]
Medina, Carlos A. [1 ]
机构：
[1] Univ Miami, Jackson Mem Hosp, Div Female Pelv Med & Reconstruct Surg, Dept Obstet & Gynecol D 50,Miller Sch Med, Miami, FL 33010 USA
[2] Univ Miami, Miller Sch Med, Dept Pathol, Miami, FL 33010 USA
[3] Univ Miami, Miller Sch Med, Dept Anesthesiol, Miami, FL 33010 USA
[4] Univ Miami, Miller Sch Med, Diabet Res Inst, Miami, FL 33010 USA
来源：
INTERNATIONAL UROGYNECOLOGY JOURNAL | 2009年 / 20卷 / 02期
关键词：
Cystocele; Fibulin; Prolapse; PELVIC ORGAN PROLAPSE; ELASTIC FIBER HOMEOSTASIS; CUTIS LAXA; URINARY-INCONTINENCE; MACULAR DEGENERATION; SMOOTH-MUSCLE; IN-VIVO; PROTEIN; GENE; STRESS;
D O I：
10.1007/s00192-008-0757-x
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The aim of this study was to compare fibulin-5 expression in women with and without anterior vaginal wall prolapse. Vaginal tissues were sampled in a standardized fashion from women with (n = 12) or without (n = 10) anterior vaginal wall prolapse. Quantitative real-time polymerase chain reaction was performed to measure mRNA levels of fibulin-5 (FIB-5). FIB-5 protein expression was assessed by immunohistochemistry. There were no significant differences in demographic data between the two groups. FIB-5 mRNA expression was significantly decreased in women with anterior vaginal wall prolapse compared to women without prolapse [(FIB-5 mean +/- SD mRNA expression in relative units) 0.01 +/- 0.01 vs. 0.09 +/- 0.14, P = 0.04]. Fibulin-5 staining intensity was diminished in women with prolapse compared to women without prolapse [intensity score, median (range), 1 (1-2) vs. 3 (2-3), P = 0.04]. Fibulin-5 expression is decreased in vaginal biopsies from women with prolapse. Changes in fibulin expression may play a role in the development of pelvic organ prolapse.
引用
收藏
页码：207 / 211
页数：5
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