MAHMI database: a comprehensive MetaHit-based resource for the study of the mechanism of action of the human microbiota

被引:24
作者
Blanco-Miguez, Aitor [1 ,2 ]
Gutierrez-Jacome, Alberto [1 ]
Fdez-Riverola, Florentino [1 ]
Lourenco, Analia [1 ,3 ]
Sanchez, Borja [2 ]
机构
[1] Univ Vigo, ESEI Dept Comp Sci, Edificio Politecn,Campus Univ As Lagoas S-N, Orense 32004, Spain
[2] CSIC, IPLA, Dept Microbiol & Biochem Dairy Prod, Villaviciosa, Asturias, Spain
[3] Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal
来源
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION | 2017年
关键词
INFLAMMATORY-BOWEL-DISEASE; GUT MICROBIOTA; INTESTINAL HOMEOSTASIS; CROHNS-DISEASE; COMMENSALS; PROTEINS; BIOLOGY;
D O I
10.1093/database/baw157
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The Mechanism of Action of the Human Microbiome (MAHMI) database is a unique resource that provides comprehensive information about the sequence of potential immunomodulatory and antiproliferative peptides encrypted in the proteins produced by the human gut microbiota. Currently, MAHMI database contains over 300 hundred million peptide entries, with detailed information about peptide sequence, sources and potential bioactivity. The reference peptide data section is curated manually by domain experts. The in silico peptide data section is populated automatically through the systematic processing of publicly available exoproteomes of the human microbiome. Bioactivity prediction is based on the global alignment of the automatically processed peptides with experimentally validated immunomodulatory and antiproliferative peptides, in the reference section. MAHMI provides researchers with a comparative tool for inspecting the potential immunomodulatory or antiproliferative bioactivity of new amino acidic sequences and identifying promising peptides to be further investigated. Moreover, researchers are welcome to submit new experimental evidence on peptide bioactivity, namely, empiric and structural data, as a proactive, expert means to keep the database updated and improve the implemented bioactivity prediction method. Bioactive peptides identified by MAHMI have a huge biotechnological potential, including the manipulation of aberrant immune responses and the design of new functional ingredients/foods based on the genetic sequences of the human microbiome. Hopefully, the resources provided by MAHMI will be useful to those researching gastrointestinal disorders of autoimmune and inflammatory nature, such as Inflammatory Bowel Diseases. MAHMI database is routinely updated and is available free of charge. Database URL: http://mahmi.org/
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页数:10
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