DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
|
2017年
关键词:
INFLAMMATORY-BOWEL-DISEASE;
GUT MICROBIOTA;
INTESTINAL HOMEOSTASIS;
CROHNS-DISEASE;
COMMENSALS;
PROTEINS;
BIOLOGY;
D O I:
10.1093/database/baw157
中图分类号:
Q [生物科学];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
The Mechanism of Action of the Human Microbiome (MAHMI) database is a unique resource that provides comprehensive information about the sequence of potential immunomodulatory and antiproliferative peptides encrypted in the proteins produced by the human gut microbiota. Currently, MAHMI database contains over 300 hundred million peptide entries, with detailed information about peptide sequence, sources and potential bioactivity. The reference peptide data section is curated manually by domain experts. The in silico peptide data section is populated automatically through the systematic processing of publicly available exoproteomes of the human microbiome. Bioactivity prediction is based on the global alignment of the automatically processed peptides with experimentally validated immunomodulatory and antiproliferative peptides, in the reference section. MAHMI provides researchers with a comparative tool for inspecting the potential immunomodulatory or antiproliferative bioactivity of new amino acidic sequences and identifying promising peptides to be further investigated. Moreover, researchers are welcome to submit new experimental evidence on peptide bioactivity, namely, empiric and structural data, as a proactive, expert means to keep the database updated and improve the implemented bioactivity prediction method. Bioactive peptides identified by MAHMI have a huge biotechnological potential, including the manipulation of aberrant immune responses and the design of new functional ingredients/foods based on the genetic sequences of the human microbiome. Hopefully, the resources provided by MAHMI will be useful to those researching gastrointestinal disorders of autoimmune and inflammatory nature, such as Inflammatory Bowel Diseases. MAHMI database is routinely updated and is available free of charge. Database URL: http://mahmi.org/
机构:
Imperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Al-Hassi, Hafid O.
;
Mann, Elizabeth R.
论文数: 0引用数: 0
h-index: 0
机构:
Imperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Mann, Elizabeth R.
;
论文数: 引用数:
h-index:
机构:
Sanchez, Borja
;
English, Nicholas R.
论文数: 0引用数: 0
h-index: 0
机构:
Imperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
English, Nicholas R.
;
Peake, Simon T. C.
论文数: 0引用数: 0
h-index: 0
机构:
Imperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
North West London Hosp NHS Trust, St Marks Hosp, Harrow, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Peake, Simon T. C.
;
Landy, Jonathan
论文数: 0引用数: 0
h-index: 0
机构:
Imperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
North West London Hosp NHS Trust, St Marks Hosp, Harrow, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Landy, Jonathan
;
Man, Ripple
论文数: 0引用数: 0
h-index: 0
机构:
North West London Hosp NHS Trust, St Marks Hosp, Harrow, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Man, Ripple
;
Urdaci, Maria
论文数: 0引用数: 0
h-index: 0
机构:
Ecole Natl Super Sci Agron Bordeaux, Lab Microbiol & Biochim Appl, Gradignan, FranceImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Urdaci, Maria
;
Hart, Ailsa L.
论文数: 0引用数: 0
h-index: 0
机构:
North West London Hosp NHS Trust, St Marks Hosp, Harrow, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Hart, Ailsa L.
;
Fernandez-Salazar, Luis
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Clin Univ Valladolid, Gastroenterol Serv, Valladolid, SpainImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Fernandez-Salazar, Luis
;
Lee, Gui Han
论文数: 0引用数: 0
h-index: 0
机构:
Imperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
North West London Hosp NHS Trust, St Marks Hosp, Harrow, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Lee, Gui Han
;
Garrote, Jose A.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Univ Rio Hortega, Dept Genet & Mol Biol, Clin Lab Serv, Valladolid, SpainImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
机构:
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil
Basso, P. J.
;
Fonseca, M. T. C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil
Fonseca, M. T. C.
;
Bonfa, G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil
Bonfa, G.
;
Alves, V. B. F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil
Alves, V. B. F.
;
Sales-Campos, H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil
Sales-Campos, H.
;
Nardini, V.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil
Nardini, V.
;
Cardoso, C. R. B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil
机构:
Imperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Al-Hassi, Hafid O.
;
Mann, Elizabeth R.
论文数: 0引用数: 0
h-index: 0
机构:
Imperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Mann, Elizabeth R.
;
论文数: 引用数:
h-index:
机构:
Sanchez, Borja
;
English, Nicholas R.
论文数: 0引用数: 0
h-index: 0
机构:
Imperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
English, Nicholas R.
;
Peake, Simon T. C.
论文数: 0引用数: 0
h-index: 0
机构:
Imperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
North West London Hosp NHS Trust, St Marks Hosp, Harrow, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Peake, Simon T. C.
;
Landy, Jonathan
论文数: 0引用数: 0
h-index: 0
机构:
Imperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
North West London Hosp NHS Trust, St Marks Hosp, Harrow, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Landy, Jonathan
;
Man, Ripple
论文数: 0引用数: 0
h-index: 0
机构:
North West London Hosp NHS Trust, St Marks Hosp, Harrow, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Man, Ripple
;
Urdaci, Maria
论文数: 0引用数: 0
h-index: 0
机构:
Ecole Natl Super Sci Agron Bordeaux, Lab Microbiol & Biochim Appl, Gradignan, FranceImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Urdaci, Maria
;
Hart, Ailsa L.
论文数: 0引用数: 0
h-index: 0
机构:
North West London Hosp NHS Trust, St Marks Hosp, Harrow, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Hart, Ailsa L.
;
Fernandez-Salazar, Luis
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Clin Univ Valladolid, Gastroenterol Serv, Valladolid, SpainImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Fernandez-Salazar, Luis
;
Lee, Gui Han
论文数: 0引用数: 0
h-index: 0
机构:
Imperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
North West London Hosp NHS Trust, St Marks Hosp, Harrow, Middx, EnglandImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
Lee, Gui Han
;
Garrote, Jose A.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Univ Rio Hortega, Dept Genet & Mol Biol, Clin Lab Serv, Valladolid, SpainImperial Coll London, Antigen Presentat Res Grp, Harrow HA1 3UJ, Middx, England
机构:
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil
Basso, P. J.
;
Fonseca, M. T. C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil
Fonseca, M. T. C.
;
Bonfa, G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil
Bonfa, G.
;
Alves, V. B. F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil
Alves, V. B. F.
;
Sales-Campos, H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil
Sales-Campos, H.
;
Nardini, V.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil
Nardini, V.
;
Cardoso, C. R. B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Imunol & Bioquim, BR-14040903 Ribeirao Preto, SP, Brazil