Changes of Amide Proton Transfer Imaging in Multiple System Atrophy Parkinsonism Type

被引:4
|
作者
Li, Shuhua [1 ,2 ]
Chan, Piu [1 ]
Li, Chunmei [3 ]
Chen, Haibo [2 ]
Chen, Min [3 ]
Su, Wen [2 ]
Li, Kai [2 ]
Lu, Na [3 ,4 ]
Yu, Lu [3 ]
Chu, Defa [5 ]
Wu, Pu-Yeh [6 ]
机构
[1] Capital Med Univ, Xuanwu Hosp, Dept Neurobiol & Neurol, Beijing, Peoples R China
[2] Chinese Acad Med Sci, Beijing Hosp, Natl Ctr Gerontol, Dept Neurol,Inst Geriatr Med, Beijing, Peoples R China
[3] Chinese Acad Med Sci, Beijing Hosp, Natl Ctr Gerontol, Dept Radiol,Inst Geriatr Med, Beijing, Peoples R China
[4] Peking Union Med Coll, Grad Sch, Beijing, Peoples R China
[5] Chinese Acad Med Sci, Inst Geriatr Med, Beijing Hosp, Dept Stat,Natl Ctr Gerontol, Beijing, Peoples R China
[6] MR Res China, GE Healthcare, Beijing, Peoples R China
来源
FRONTIERS IN AGING NEUROSCIENCE | 2020年 / 12卷
基金
国家重点研发计划;
关键词
APT imaging; magnetic resonance imaging; biomarker; multiple system atrophy; parkinsonism; MAGNETIZATION-TRANSFER RATIO; ISCHEMIC PENUMBRA; DISEASE; CEST; NEUROPATHOLOGY; ABNORMALITIES; PROTEINS; GLIOMA; MRI;
D O I
10.3389/fnagi.2020.572421
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Multiple system atrophy (MSA), an atypical parkinsonism of alpha-synucleinopathies, has no specific biomarker of diagnosis. According to different combinations of symptoms, MSA can be classified as parkinsonism-type MSA (MSA-P) and cerebellar-type MSA (MSA-C; Watanabe et al.,2018). Amide proton transfer (APT) imaging is by far the most studied chemical exchange saturation transfer imaging for its sensitivity to mobile protons and peptides in tissues. We hypothesize that APT imaging may be a feasible biomarker of MSA-P. Twenty MSA-P patients and 20 age-matched normal controls were enrolled in this study and underwent MR exams on a 3.0-T MR scanner. Magnetization transfer spectra at 3.5 ppm were acquired at two transverse slices of the head, including the midbrain and the basal ganglia. Mann-WhitneyUtest was used to compare the asymmetrical magnetization transfer ratio (MTRasym) difference between MSA-P patients and normal controls. The APT MTR(asym)values of MSA patients in the red nucleus (RN) (SN;P= 0.000), substantia nigra (P= 0.000), thalamus (P= 0.000), and putamen (P= 0.013) were significantly higher than those in normal controls. There was a negative correlation between APT MTR(asym)and the score of part III of the Unified Parkinson Disease Rating Scale (R= -0.338,P= 0.044) in the putamen, while there was a positive correlation between the APT MTR(asym)and the rate of motor symptom progression (R= 0.406,P= 0.017) in the RN. These findings suggest that APT MTR(asym)changes are found and may be of value in the diagnosis of MSA-P.
引用
收藏
页数:10
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