Chromogranin A, Ki-67 index and IGF-related genes in patients with neuroendocrine tumors

被引：11

作者：

van Adrichem, R. C. S. ^{[1
]}

Hofland, L. J. ^{[1
]}

Feelders, R. A. ^{[1
]}

De Martino, M. C. ^{[1
]}

van Koetsveld, P. M. ^{[1
]}

van Eijck, C. H. J. ^{[2
]}

de Krijger, R. R. ^{[3
,4
]}

Sprij-Mooij, D. M. ^{[1
]}

Janssen, J. A. M. J. L. ^{[1
]}

de Herder, W. W. ^{[1
]}

机构：

[1] Erasmus MC, Sector Endocrinol, Dept Internal Med, S Gravendijkwal 230,Room D-430, NL-3015 CE Rotterdam, Netherlands

[2] Erasmus MC, Dept Surg, Rotterdam, Netherlands

[3] Erasmus MC, Dept Pathol, Rotterdam, Netherlands

[4] Reinier de Graaf Hosp, Delft, Netherlands

来源：

ENDOCRINE CONNECTIONS | 2013年 / 2卷 / 04期

关键词：

gastroenteropancreatic neuroendocrine tumors (GEP NETs); IGF-related genes; Ki-67 proliferation index; serum chromogranin A (sCgA);

D O I：

10.1530/EC-13-0052

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chromogranin A (CgA) and the Ki-67 proliferation index are considered as important biochemical and pathological markers for clinical behaviour of gastroenteropancreatic neuroendocrine tumors (GEP NETs), respectively. The IGF system has been suggested as an important regulator of GEP NET proliferation and differentiation. A possible relationship between serum CgA (sCgA), Ki-67 proliferation index, and expression of IGF-related genes in patients with GEP NETs has not been demonstrated yet. This study investigates the relationship between sCgA, the Ki-67 proliferation index, and the expression of IGF-related genes in GEP NET tissues and their relation with 5-year survival. Tumor and blood samples from 22 GEP NET patients were studied. Tumoral mRNA expression of IGF-related genes (IGFs: IGF1, IGF2; IGF receptors: IGF1R, IGF2R; insulin receptors: subtype A (IR-A) and B (IR-B); IGF-binding proteins (IGFBPs): IGFBP1, IGFBP2, IGFBP3, and IGFBP6) was measured using quantitative RT-PCR. Ki-67 proliferation index was determined using immunohistochemistry. sCgA was measured with ELISA. Five-year survival in patients with nonelevated sCgA (n=11) was 91 vs 46% in patients with elevated sCgA (n=11) (P=0.006). IR-A mRNA expression was significantly higher in tumors obtained from patients with elevated sCgA than in those from patients with nonelevated sCgA (6.42 +/- 2.08 vs 2.60 +/- 0.40; P=0.04). This data suggests that sCgA correlates well with 5-year survival of GEP NET patients, and that IR-A mRNA expression correlates well with tumor mass in GEP NET patients.

引用

页码：172 / 177

页数：6