Antiviral Phenolic Compounds from Arundina gramnifolia

被引：185

作者：

Hu, Qiu-Fen ^{[1
,2
,3
]}

Zhou, Bin ^{[1
,2
,4
]}

Huang, Jian-Ming ^{[3
,5
]}

Gao, Xue-Mei ^{[1
,2
]}

Shu, Li-Dan ^{[1
,2
]}

Yang, Guang-Yu ^{[1
,2
,4
]}

Che, Chun-Tao ^{[3
]}

机构：

[1] Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Yunnan, Peoples R China

[2] Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Yunnan, Peoples R China

[3] Univ Illinois, Dept Med Chem & Pharmacognosy, Coll Pharm, Chicago, IL 60612 USA

[4] Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 650106, Yunnan, Peoples R China

[5] Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 02期

关键词：

MOSAIC-VIRUS; DERIVATIVES; CONSTITUENTS; GRAMINIFOLIA;

D O I：

10.1021/np300727f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new phenolic compounds, gramniphenols C-G (1-5), and eight known compounds (6-13) were isolated from the whole plant of Arundina gramnifolia. Compounds 1, 4, and 5 showed anti-tobacco mosaic virus activity, with IC50 values of 20.8, 40.8, and 57.7 mu M, respectively. Compounds 1-10 were also tested for their anti-HIV-1 activity; compounds 2, 3, and 6 displayed anti-HIV-1 activity with therapeutic index values above 100:1.

引用

页码：292 / 296

页数：5

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