Antiviral Phenolic Compounds from Arundina gramnifolia

被引：182
作者：
Hu, Qiu-Fen [1 ,2 ,3 ]
Zhou, Bin [1 ,2 ,4 ]
Huang, Jian-Ming [3 ,5 ]
Gao, Xue-Mei [1 ,2 ]
Shu, Li-Dan [1 ,2 ]
Yang, Guang-Yu [1 ,2 ,4 ]
Che, Chun-Tao [3 ]
机构：
[1] Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Yunnan, Peoples R China
[2] Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Yunnan, Peoples R China
[3] Univ Illinois, Dept Med Chem & Pharmacognosy, Coll Pharm, Chicago, IL 60612 USA
[4] Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 650106, Yunnan, Peoples R China
[5] Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 02期
关键词：
MOSAIC-VIRUS; DERIVATIVES; CONSTITUENTS; GRAMINIFOLIA;
D O I：
10.1021/np300727f
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Five new phenolic compounds, gramniphenols C-G (1-5), and eight known compounds (6-13) were isolated from the whole plant of Arundina gramnifolia. Compounds 1, 4, and 5 showed anti-tobacco mosaic virus activity, with IC50 values of 20.8, 40.8, and 57.7 mu M, respectively. Compounds 1-10 were also tested for their anti-HIV-1 activity; compounds 2, 3, and 6 displayed anti-HIV-1 activity with therapeutic index values above 100:1.
引用
收藏
页码：292 / 296
页数：5
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