Delivering precision antimicrobial therapy through closed-loop control systems

被引：31

作者：

Rawson, T. M. ^{[1
]}

O'Hare, D. ^{[2
]}

Herrero, P. ^{[3
]}

Sharma, S. ^{[4
]}

Moore, L. S. P. ^{[1
,5
]}

de Barra, E. ^{[5
]}

Roberts, J. A. ^{[6
,7
,8
]}

Gordon, A. C. ^{[9
]}

Hope, W. ^{[10
]}

Georgiou, P. ^{[3
]}

Cass, A. E. G. ^{[11
,12
]}

Holmes, A. H. ^{[1
,5
]}

机构：

[1] Imperial Coll London, Hlth Protect Res Unit Healthcare Associated Infec, Natl Inst Hlth Res, Hammersmith Campus,Du Cane Rd, London W12 0NN, England

[2] Imperial Coll London, Dept Bioengn, London SW7 2AZ, England

[3] Imperial Coll London, Dept Elect & Elect Engn, South Kensington Campus, London SW7 2AZ, England

[4] Swansea Univ, Coll Engn, Swansea SA1 8EN, W Glam, Wales

[5] Imperial Coll Healthcare NHS Trust, Hammersmith Hosp, Du Cane Rd, London W12 0NN, England

[6] Univ Queensland, Fac Med, Clin Res Ctr, Brisbane, Qld, Australia

[7] Univ Queensland, Sch Pharm, Ctr Translat Pharmacodynam, Brisbane, Qld, Australia

[8] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia

[9] Imperial Coll London, Sect Anaesthet Pain Med & Intens Care, London SW7 2AZ, England

[10] Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool L69 3GE, Merseyside, England

[11] Imperial Coll London, Dept Chem, Kensington Campus, London SW7 2AZ, England

[12] Imperial Coll London, Inst Biomed Engn, Kensington Campus, London SW7 2AZ, England

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2018年 / 73卷 / 04期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

CRITICALLY-ILL PATIENTS; TRANSDERMAL DRUG-DELIVERY; BETA-LACTAM ANTIBIOTICS; FIELD-EFFECT TRANSISTORS; GLASSY-CARBON ELECTRODE; FLOW-INJECTION ANALYSIS; POPULATION PHARMACOKINETICS; ELECTROCHEMICAL DETECTION; GRAPHENE OXIDE; AMINOGLYCOSIDE ANTIBIOTICS;

D O I：

10.1093/jac/dkx458

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true individualization of therapy. These include problems with plasma drug sampling, availability of appropriate assays, and current mechanisms for dose adjustment. Biosensor technology offers a means of providing real-time monitoring of antimicrobials in a minimally invasive fashion. We report the potential for using microneedle biosensor technology as part of closed-loop control systems for the optimization of antimicrobial therapy in individual patients.

引用

页码：835 / 843

页数：9

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