Antiallodynic and Analgesic Effects of Maslinic Acid, a Pentacyclic Triterpenoid from Olea europaea

被引：24

作者：

Nieto, Francisco R. ^{[1
,2
]}

Cobos, Enrique J. ^{[1
,2
]}

Entrena, Jose M. ^{[3
]}

Parra, Andres ^{[4
]}

Garcia-Granados, Andres ^{[4
]}

Baeyens, Jose M. ^{[1
,2
]}

机构：

[1] Univ Granada, Sch Med, Dept Pharmacol, Granada 18012, Spain

[2] Univ Granada, Biomed Res Ctr, Inst Neurosci, Granada 18100, Spain

[3] Univ Granada, Sci Instrumentat Ctr, Anim Behav Res Unit, Granada 18100, Spain

[4] Univ Granada, Fac Sci, Dept Organ Chem, Granada, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 04期

关键词：

OXIDATIVE STRESS; NEUROPATHIC PAIN; OLIVE FRUIT; MODELS; HYPERALGESIA; ANTIOXIDANT; NOCICEPTION; PACLITAXEL; RECEPTORS; APOPTOSIS;

D O I：

10.1021/np300783a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effects of maslinic acid (1), a pentacyclic triterpenoid obtained from Olea europaea, were studied in several tests for nociception in mice. Systemic administration of 1 reduced acetic acid-induced writhing, the inflammatory phase of formalin-induced pain, and capsaicin-induced mechanical allodynia. However, it did not induce motor incoordination in the rotarod test. The topical administration of 1 also reduced the inflammatory phase of the formalin test, indicating that at least some of its effects are mediated peripherally. The present results demonstrate for the first time that maslinic acid induces antinociceptive and antiallodynic effects.

引用

页码：737 / 740

页数：4

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