Toward a three-dimensional view of protein networks between species

被引：22

作者：

Franzosa, Eric A. ^{[1
]}

Garamszegi, Sara ^{[1
]}

Xia, Yu ^{[1
,2
,3
,4
,5
]}

机构：

[1] Boston Univ, Bioinformat Program, Boston, MA 02215 USA

[2] Boston Univ, Dept Chem, Boston, MA 02215 USA

[3] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

[4] Dana Farber Canc Inst, Ctr Canc Syst Biol, Boston, MA 02115 USA

[5] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

来源：

FRONTIERS IN MICROBIOLOGY | 2012年 / 3卷

基金：

美国国家科学基金会;

关键词：

structural systems biology; protein protein interaction; host pathogen interaction; bioinformatics and computational biology; network biology;

D O I：

10.3389/fmicb.2012.00428

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

General principles governing biomolecular interactions between species are expected to differ significantly from known principles governing the interactions within species, yet these principles remain poorly understood at the systems level. A key reason for this knowledge gap is the lack of a detailed three-dimensional (3D), atomistic view of biomolecular interaction networks between species. Recent progress in structural biology, systems biology, and computational biology has enabled accurate and large-scale construction of 3D structural models of nodes and edges for protein protein interaction networks within and between species. The resulting within- and between-species structural interaction networks have provided new biophysical, functional, and evolutionary insights into species interactions and infectious disease. Here, we review the nascent field of between-species structural systems biology, focusing on interactions between host and pathogens such as viruses.

引用

页数：6

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