Synthesis of C3-Quaternary 2H-Pyrrolines by [3+2] Cycloaddition of Isocyanoacetates and 1,1-Disubstituted Alkenes

被引：0
|
作者：
Cheng, Yi [1 ]
Zhang, Runmei [1 ]
Lu, Tianhao [1 ]
Shen, Yong [1 ]
Wang, Min [1 ]
Xie, Chunsong [1 ]
机构：
[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 311121, Peoples R China
来源：
LETTERS IN ORGANIC CHEMISTRY | 2020年 / 17卷 / 08期
关键词：
2H-pyrroline; copper catalysis; isocyanoacetate; isonitrile; cycloaddition; quaternary carbon; ASYMMETRIC DOMINO REACTION; REACTIVITY; SCAFFOLDS;
D O I：
10.2174/1570178617666191218104959
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Under mild conditions, C3-quaternary 2H-pyrrolines can be convergently and efficiently assembled by Cu(II) and weak bases cocatalyzed [3+2] cycloaddition of 1,1-disubstituted alkenes and isocyanoacetates. Various functionalities can be tolerated, affording 2H-pyrrolines with up to two quaternary centers in a single step.
引用
收藏
页码：586 / 589
页数：4
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