Natural Polyphenols for Prevention and Treatment of Cancer

被引：536

作者：

Zhou, Yue ^{[1
]}

Zheng, Jie ^{[1
]}

Li, Ya ^{[1
]}

Xu, Dong-Ping ^{[1
]}

Li, Sha ^{[2
]}

Chen, Yu-Ming ^{[1
]}

Li, Hua-Bin ^{[1
,3
]}

机构：

[1] Sun Yat Sen Univ, Guangdong Prov Key Lab Food Nutr & Hlth, Sch Publ Hlth, Guangzhou 510080, Guangdong, Peoples R China

[2] Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China

[3] Sun Yat Sen Univ, South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510006, Guangdong, Peoples R China

来源：

NUTRIENTS | 2016年 / 8卷 / 08期

基金：

中国国家自然科学基金;

关键词：

polyphenol; flavonoid; anticancer; antioxidant; anti-inflammation; CELL-CYCLE ARREST; EPITHELIAL-MESENCHYMAL TRANSITION; POTENTIAL ANTICANCER PROPERTIES; DIETARY FLAVONOID INTAKE; TOTAL PHENOLIC CONTENTS; BREAST-CARCINOMA CELLS; PROSTATE-CANCER; COLORECTAL-CANCER; HEPATOCELLULAR-CARCINOMA; INHIBITS PROLIFERATION;

D O I：

10.3390/nu8080515

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

There is much epidemiological evidence that a diet rich in fruits and vegetables could lower the risk of certain cancers. The effect has been attributed, in part, to natural polyphenols. Besides, numerous studies have demonstrated that natural polyphenols could be used for the prevention and treatment of cancer. Potential mechanisms included antioxidant, anti-inflammation as well as the modulation of multiple molecular events involved in carcinogenesis. The current review summarized the anticancer efficacy of major polyphenol classes (flavonoids, phenolic acids, lignans and stilbenes) and discussed the potential mechanisms of action, which were based on epidemiological, in vitro, in vivo and clinical studies within the past five years.

引用

页数：35

共 201 条

[1]

Abdel H.L., 2015, PLOS ONE, V10

[2] Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death [J].

Aires, Virginie ;

Limagne, Emeric ;

Cotte, Alexia K. ;

Latruffe, Norbert ;

Ghiringhelli, Francois ;

Delmas, Dominique .

MOLECULAR NUTRITION & FOOD RESEARCH, 2013, 57 (07) :1170-1181

[3] The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways [J].

Alshatwi, Ali A. ;

Ramesh, E. ;

Periasamy, V. S. ;

Subash-Babu, P. .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2013, 27 (06) :581-592

[4] Long-term exposure to dietary sources of genistein induces estrogen-independence in the human breast cancer (MCF-7) xenograft model [J].

Andrade, Juan E. ;

Ju, Young H. ;

Baker, Chandra ;

Doerge, Daniel R. ;

Helferich, William G. .

MOLECULAR NUTRITION & FOOD RESEARCH, 2015, 59 (03) :413-423

[5]

[Anonymous], 2016, TUMOUR BIOL

[6] RETRACTED: Antiproliferative Efficacy of Hesperetin (Citrus Flavanoid) in 1,2-Dimethylhydrazine-Induced Colon Cancer (Retracted Article) [J].

Aranganathan, Selvaraj ;

Nalini, Namasivayam .

PHYTOTHERAPY RESEARCH, 2013, 27 (07) :999-1005

[7] Naringenin (Citrus Flavonone) Induces Growth Inhibition, Cell Cycle Arrest and Apoptosis in Human Hepatocellular Carcinoma Cells [J].

Arul, Duraikannu ;

Subramanian, Perumal .

PATHOLOGY & ONCOLOGY RESEARCH, 2013, 19 (04) :763-770

[8] The Chemopreventive Effect of the Dietary Compound Kaempferol on the MCF-7 Human Breast Cancer Cell Line Is Dependent on Inhibition of Glucose Cellular Uptake [J].

Azevedo, Claudia ;

Correia-Branco, Ana ;

Araujo, Joao R. ;

Guimaraes, Joao T. ;

Keating, Elisa ;

Martel, Fatima .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2015, 67 (03) :504-513

[9] Flaxseed-Derived Enterolactone Is Inversely Associated with Tumor Cell Proliferation in Men with Localized Prostate Cancer [J].

Azrad, Maria ;

Vollmer, Robin T. ;

Madden, John ;

Dewhirst, Mark ;

Polascik, Thomas J. ;

Snyder, Denise C. ;

Ruffin, Mack T. ;

Moul, Judd W. ;

Brenner, Dean E. ;

Demark-Wahnefried, Wendy .

JOURNAL OF MEDICINAL FOOD, 2013, 16 (04) :357-360

[10] Delphinidin, a dietary anthocyanidin in pigmented fruits and vegetables A new weapon to blunt prostate cancer growth [J].

Bin Hafeez, Bilal ;

Asim, Mohammad ;

Siddiqui, Imtiaz Ahmad ;

Adhami, Vaqar Mustafa ;

Murtaza, Imtiyaz ;

Mukhtar, Hasan .

CELL CYCLE, 2008, 7 (21) :3320-3326

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