Structure-Activity Relationship of a Broad-Spectrum Insect Odorant Receptor Agonist

被引：47

作者：

Taylor, Robert W. ^{[1
]}

Romaine, Ian M. ^{[2
]}

Liu, Chao ^{[1
]}

Murthi, Poornima ^{[1
]}

Jones, Patrick L. ^{[1
]}

Waterson, Alex G. ^{[2
,3
]}

Sulikowski, Gary A. ^{[2
]}

Zwiebel, Laurence J. ^{[1
,3
,4
,5
]}

机构：

[1] Vanderbilt Univ, Dept Biol Sci, Vanderbilt Inst Chem Biol, Nashville, TN 37235 USA

[2] Vanderbilt Univ, Dept Chem, Vanderbilt Inst Chem Biol, Nashville, TN 37235 USA

[3] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37235 USA

[4] Vanderbilt Univ, Med Ctr, Inst Global Hlth, Ctr Mol Neurosci, Nashville, TN 37235 USA

[5] Vanderbilt Univ, Med Ctr, Program Dev Biol, Nashville, TN 37235 USA

来源：

ACS CHEMICAL BIOLOGY | 2012年 / 7卷 / 10期

基金：

美国国家卫生研究院;

关键词：

CONSERVATION; BEHAVIOR;

D O I：

10.1021/cb300331z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Agonism of insect odorant receptor (OR) cation channels may represent a new strategy for the manipulation of destructive insect olfactory-driven behaviors. We have explored the chemical space around VUAA1, the first in class agonist of the obligate OR co-receptor ion channel (Orco), and describe novel compound analogues with increased potency across insect taxa. Functional analyses reveal several of these VUAA1 structural analogues display significantly greater potency as compared to the activity of the previously described active compounds in mobility-based behavioral assays on mosquito larvae.

引用

页码：1647 / 1652

页数：6

共 50 条

[31] THE INVIVO ANTIFUNGAL ACTIVITY OF BROAD-SPECTRUM AZOLES
VANCUTSEM, J
VANGERVEN, F
DRUG DEVELOPMENT RESEARCH, 1986, 8 (1-4) : 309 - 316
[32] MACROLIDES, A GROUP OF ANTIBIOTICS WITH A BROAD-SPECTRUM OF ACTIVITY
HOF, H
IMMUNITAT UND INFEKTION, 1994, 22 (02): : 66 - 71
[33] PENBRITIN - AN ORAL PENICILLIN WITH BROAD-SPECTRUM ACTIVITY
STEWART, GT
HOLT, RJ
COLES, HMT
NIXON, HH
BMJ-BRITISH MEDICAL JOURNAL, 1961, 2 (5246): : 200 - +
[34] NEW NUCLEOSIDES WITH BROAD-SPECTRUM ANTIVIRAL ACTIVITY
ROBINS, RK
REVANKAR, GR
SRIVASTAVA, PC
KIRSI, J
NORTH, JA
MURRAY, B
MCKERNAN, PA
CANONICO, PG
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1983, 185 (MAR): : 45 - CARB
[35] NOVEL OLIGONUCLEOTIDES WITH BROAD-SPECTRUM ANTIVIRAL ACTIVITY
MEYER, RB
GALL, AA
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 207 : 40 - CARB
[36] SCH-51048, A NOVEL BROAD-SPECTRUM ORALLY-ACTIVE ANTIFUNGAL AGENT - SYNTHESIS AND PRELIMINARY STRUCTURE-ACTIVITY PROFILE
SAKSENA, AK
GIRIJAVALLABHAN, VM
LOVEY, RG
DESAI, JA
PIKE, RE
JAO, E
WANG, HY
GANGULY, AK
LOEBENBERG, D
HARE, RS
CACCIAPUOTI, A
PARMEGIANI, RM
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (02) : 127 - 132
[37] A gene cluster encoding lectin receptor kinases confers broad-spectrum and durable insect resistance in rice
Liu, Yuqiang
Wu, Han
Chen, Hong
Liu, Yanling
He, Jun
Kang, Haiyan
Sun, Zhiguang
Pan, Gen
Wang, Qi
Hu, Jinlong
Zhou, Feng
Zhou, Kunneng
Zheng, Xiaoming
Ren, Yulong
Chen, Liangming
Wang, Yihua
Zhao, Zhigang
Lin, Qibing
Wu, Fuqing
Zhang, Xin
Guo, Xiuping
Cheng, Xianian
Jiang, Ling
Wu, Chuanyin
Wang, Haiyang
Wan, Jianmin
NATURE BIOTECHNOLOGY, 2015, 33 (03) : 301 - +
[38] A gene cluster encoding lectin receptor kinases confers broad-spectrum and durable insect resistance in rice
Yuqiang Liu
Han Wu
Hong Chen
Yanling Liu
Jun He
Haiyan Kang
Zhiguang Sun
Gen Pan
Qi Wang
Jinlong Hu
Feng Zhou
Kunneng Zhou
Xiaoming Zheng
Yulong Ren
Liangming Chen
Yihua Wang
Zhigang Zhao
Qibing Lin
Fuqing Wu
Xin Zhang
Xiuping Guo
Xianian Cheng
Ling Jiang
Chuanyin Wu
Haiyang Wang
Jianmin Wan
Nature Biotechnology, 2015, 33 : 301 - 305
[39] Insect Repellents: Modulators of Mosquito Odorant Receptor Activity
Bohbot, Jonathan D.
Dickens, Joseph C.
PLOS ONE, 2010, 5 (08):
[40] STRUCTURE OF MICROCIN C51, A NEW ANTIBIOTIC WITH A BROAD-SPECTRUM OF ACTIVITY
METLITSKAYA, AZ
KATRUKHA, GS
SHASHKOV, AS
ZAITSEV, DA
EGOROV, TA
KHMEL, IA
FEBS LETTERS, 1995, 357 (03) : 235 - 238

← 1 2 3 4 5 →