Quantitative spectroscopic photoacoustic imaging: a review

被引：569

作者：

Cox, Ben ^{[1
]}

Laufer, Jan G. ^{[1
]}

Arridge, Simon R. ^{[2
]}

Beard, Paul C. ^{[1
]}

机构：

[1] UCL, Dept Med Phys & Bioengn, London WC1E 6BT, England

[2] UCL, Dept Comp Sci, London WC1E 6BT, England

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2012年 / 17卷 / 06期

基金：

英国医学研究理事会; 英国工程与自然科学研究理事会;

关键词：

imaging; inverse problems; photoacoustics; spectroscopy; OPTICAL-ABSORPTION COEFFICIENT; MULTISPECTRAL OPTOACOUSTIC TOMOGRAPHY; TIME-RESOLVED DETECTION; BLOOD OXYGENATION; CHROMOPHORE CONCENTRATIONS; THERMOACOUSTIC TOMOGRAPHY; HEMOGLOBIN CONCENTRATION; SCATTERING MEDIA; VASCULAR TISSUE; LIGHT TRANSPORT;

D O I：

10.1117/1.JBO.17.6.061202

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Obtaining absolute chromophore concentrations from photoacoustic images obtained at multiple wavelengths is a nontrivial aspect of photoacoustic imaging but is essential for accurate functional and molecular imaging. This topic, known as quantitative photoacoustic imaging, is reviewed here. The inverse problems involved are described, their nature (nonlinear and ill-posed) is discussed, proposed solution techniques and their limitations are explained, and the remaining unsolved challenges are introduced. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.6.061202]

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页数：22

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