Flavonoids: biosynthesis, biological functions, and biotechnological applications

被引：1332
作者：
Falcone Ferreyra, Maria L. [1 ]
Rius, Sebastian P. [1 ]
Casati, Paula [1 ]
机构：
[1] Univ Nacl Rosario, Ctr Estudios Fotosintet & Bioquim, RA-2000 Rosario, Santa Fe, Argentina
来源：
FRONTIERS IN PLANT SCIENCE | 2012年 / 3卷
关键词：
flavonoid; transcription factors; genetic engineering; defense; combinatorial biosynthesis; ULTRAVIOLET-B RADIATION; FLOWER COLOR MODIFICATION; ARABIDOPSIS-THALIANA; AUXIN TRANSPORT; MEDICAGO-TRUNCATULA; CHALCONE SYNTHASE; ZEA-MAYS; ANTHOCYANIN BIOSYNTHESIS; ESCHERICHIA-COLI; CORN-EARWORM;
D O I：
10.3389/fpls.2012.00222
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Flavonoids are widely distributed secondary metabolites with different metabolic functions in plants. The elucidation of the biosynthetic pathways, as well as their regulation by MYB, basic helix-loop-helix (bHLH), and WD40-type transcription factors, has allowed metabolic engineering of plants through the manipulation of the different final products with valuable applications. The present review describes the regulation of flavonoid biosynthesis, as well as the biological functions of flavonoids in plants, such as in defense against UV-B radiation and pathogen infection, nodulation, and pollen fertility. In addition, we discuss different strategies and achievements through the genetic engineering of flavonoid biosynthesis with implication in the industry and the combinatorial biosynthesis in microorganisms by the reconstruction of the pathway to obtain high amounts of specific compounds.
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页数：15
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