The roles of miRNAs as potential biomarkers in lung diseases

被引：130

作者：

Alipoor, Shamila D. ^{[1
,2
]}

Adcock, Ian M. ^{[3
]}

Garssen, Johan ^{[4
,5
]}

Mortaz, Esmaeil ^{[1
,3
,6
]}

Varahram, Mohammad ^{[7
]}

Mirsaeidi, Mehdi ^{[8
]}

Velayati, Aliakbar ^{[7
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Natl Res Inst TB & Lung Dis, Chron Resp Dis Res Ctr, Tehran, Iran

[2] Natl Inst Genet Engn & Biotechnol, Dept Mol Med, Inst Med Biotechnol, Tehran, Iran

[3] Imperial Coll London, Natl Heart & Lung Inst, Airways Dis Sect, Cell & Mol Biol Grp, Dovehouse St, London, England

[4] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Fac Sci, Div Pharmacol, Utrecht, Netherlands

[5] Nutricia Res Ctr Specialized Nutr, Utrecht, Netherlands

[6] Shahid Beheshti Univ Med Sci, Clin TB & Epidemiol Res Ctr, Natl Res & Inst TB & Lung Dis, Tehran, Iran

[7] Shahid Beheshti Univ Med Sci, Masih Daneshvari Hosp, Natl Res Inst TB & Lung Dis, Mycobacteriol Res Ctr, Tehran, Iran

[8] Univ Miami, Div Pulm & Crit Care, Miami, FL USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2016年 / 791卷

基金：

英国惠康基金;

关键词：

MicroRNA; Sarcoidosis; Lung cancer; Asthma; COPD; Lung disease; ALLERGIC AIRWAY INFLAMMATION; DOWN-REGULATION; MICRORNA BIOGENESIS; MUSCLE DYSFUNCTION; MIR-17-92; CLUSTER; SEED REGION; CANCER; EXPRESSION; RNA; IDENTIFICATION;

D O I：

10.1016/j.ejphar.2016.09.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs which can act as master regulators of gene expression, modulate almost all biological process and are essential for maintaining cellular homeostasis. Dysregulation of miRNA expression has been associated with aberrant gene expression and may lead to pathological conditions. Evidence suggests that miRNA expression profiles are altered between health and disease and as such may be considered as biomarkers of disease. Evidence is increasing that miRNAs are particularly important in lung homeostasis and development and have been demonstrated to be the involved in many pulmonary diseases such as asthma, COPD, sarcoidosis, lung cancer and other smoking related diseases. Better understanding of the function of miRNA and the mechanisms underlying their action in the lung, would help to improve current diagnosis and therapeutics strategies in pulmonary diseases. Recently, some miRNA-based drugs have been introduced as possible therapeutic agents. In this review we aim to summarize the recent findings regarding the role of miRNAs in the airways and lung and emphasise their potential therapeutic roles in pulmonary diseases. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：395 / 404

页数：10

共 142 条

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