A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity

被引：45
作者：
Boeck, P
Sá, MM
de Souza, BS
Cercená, R
Escalante, AM
Zachino, SA
Cechinel, V
Yunes, RA [1 ]
机构：
[1] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil
[2] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, RA-2000 Rosario, Santa Fe, Argentina
[3] Univ Vale Itajai, BR-88302202 Itajai, SC, Brazil
来源：
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2005年 / 16卷 / 6B期
关键词：
kaurenoic acid; esters; Wedelia paludosa; antifungal activity;
D O I：
10.1590/S0103-50532005000800009
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Representative esters derived from kaurenoic acid were prepared in order to evaluate their antifungal properties. Alkyl and substituted benzyl esters were obtained in good yield under mild conditions by esterification of kaurenoic acid with the corresponding alkyl halide in KOH-acetone. All synthesized compounds were tested for antifungal properties against pathogenic yeasts, hialohyphomycetes and dermatophytes. Kaurenoic acid and derivatives containing a free carboxyl group were moderately active against dermatophytes.
引用
收藏
页码：1360 / 1366
页数：7
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