Photoinduced DNA cleavage by anthracene based hydroxamic acids

被引：7

作者：

Chowdhury, Nilanjana ^{[1
]}

Dasgupta, Swagata ^{[1
]}

Singh, N. D. Pradeep ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 14期

关键词：

Hydroxamic acid; DNA cleavage; UV light; HISTONE DEACETYLASE INHIBITOR; TRICHOSTATIN-A; MATRIX-ISOLATION; IN-VITRO; OXAMFLATIN; SCRIPTAID; CELLS; PHOTOCHEMISTRY; SPECIFICITY; EXPRESSION;

D O I：

10.1016/j.bmcl.2012.05.084

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two different series of naphthalene and anthracene based hydroxamic acids having amino acid derivatives were synthesized. Single strand DNA cleavage was achieved on irradiation of newly synthesized hydroxamic acids by UV light (>= 350 nm). Both reactive oxygen species (ROS) and generated radicals from hydroxamic acids were shown to be responsible for the DNA cleavage. Further, DNA cleaving ability of hydroxamic acids was found to be dependent on its concentration and on its structure. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4668 / 4671

页数：4

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