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Genotypes B and C hepatocellular carcinoma-associated hepatitis B virus pre-S mutants: their detection among F1b and A2-but not F4-isolates from Argentina
被引:4
作者:

Trinks, J.
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机构: Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina

Frias, S.
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机构:
Hosp Ramos Mejia, Serv Hepatol, Buenos Aires, DF, Argentina Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina

Frider, B.
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机构:
Hosp Dr Cosme Argerich, Serv Hepatol, Buenos Aires, DF, Argentina Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina

Alessio, A.
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h-index: 0
机构:
Hosp Dr Cosme Argerich, Serv Hepatol, Buenos Aires, DF, Argentina Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina

Pozzati, M.
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机构:
Hosp Dr Cosme Argerich, Serv Hepatol, Buenos Aires, DF, Argentina Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina

Daleoso, G.
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机构:
Hosp Ramos Mejia, Serv Hepatol, Buenos Aires, DF, Argentina Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina

Leon, L.
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h-index: 0
机构:
Hosp Ramos Mejia, Serv Hepatol, Buenos Aires, DF, Argentina Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina

Batalla, V. M.
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h-index: 0
机构:
Hosp Pediat Prof Dr Juan P Garrahan, Buenos Aires, DF, Argentina Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina

Diaz, A.
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h-index: 0
机构:
Hosp Pediat Prof Dr Juan P Garrahan, Buenos Aires, DF, Argentina Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina

Ameigeiras, B.
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Ramos Mejia, Serv Hepatol, Buenos Aires, DF, Argentina Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina

Oubina, J. R.
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h-index: 0
机构:
Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina
机构:
[1] Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina
[2] Hosp Ramos Mejia, Serv Hepatol, Buenos Aires, DF, Argentina
[3] Hosp Dr Cosme Argerich, Serv Hepatol, Buenos Aires, DF, Argentina
[4] Hosp Pediat Prof Dr Juan P Garrahan, Buenos Aires, DF, Argentina
关键词:
Argentina;
hepatitis B virus;
hepatitis B virus genotypes;
hepatocellular carcinoma;
pre-S mutants;
D O I:
10.1111/j.1365-2893.2012.01620.x
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
. Prevalence rates of hepatocellular carcinoma (HCC)-associated hepatitis B virus (HBV) pre-S mutants among most genotypes are still lacking. In this study, viral (sub)genotypes of 70 Argentine nucleotide sequences (33 newly obtained) were determined by phylogenetic analysis, and the presence of such mutants was assessed in the American continent for the first time. Nucleotide substitutions of the pre-S2 start codon were observed in 10% of the HBV/A2 sequences. Ten per cent of the HBV/A2 and 12.5% of the HBV/F1b but none of HBV/F4 exhibited a deletion in the pre-S1/pre-S2 region. The contribution of these variants to liver cirrhosis (LC) and/or HCC development among HBV/F and HBV/A isolates deserves further prospective clinical studies.
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页码:823 / 828
页数:6
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Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

Cuestas, M. L.
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机构:
Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

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Mathet, V. L.
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机构:
Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina
Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

Minassian, M. L.
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Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina
Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

Rivero, C. W.
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Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina
Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

Benetucci, J. A.
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FUNDAI, Buenos Aires, DF, Argentina Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

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Bobillo, M. C.
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Corach, D.
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机构:
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UBA, Serv Huellas Digitales Genet & Catedra Genet Mol, Fac Farm & Bioquim, Buenos Aires, DF, Argentina Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

Ghiringhelli, P. D.
论文数: 0 引用数: 0
h-index: 0
机构:
Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina
Univ Nacl Quilmes, Lab Ingn Genet & Biol Celular Mol, Bernal, Argentina Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

Sanchez, D. O.
论文数: 0 引用数: 0
h-index: 0
机构:
Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina
Univ Nacl San Martin, San Martin, Argentina Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

Avila, M. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina
UBA, Fac Med, Dept Microbiol, Ctr Nacl Referencia SIDA, Buenos Aires, DF, Argentina Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

Peralta, L. A. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina
UBA, Fac Med, Dept Microbiol, Ctr Nacl Referencia SIDA, Buenos Aires, DF, Argentina Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

Kurbanov, F.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

Weissenbacher, M. C.
论文数: 0 引用数: 0
h-index: 0
机构:
Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina
UBA, Fac Med, Dept Microbiol, Ctr Nacl Referencia SIDA, Buenos Aires, DF, Argentina Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

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Mizokami, M.
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机构:
Nagoya City Univ, Grad Sch Med Sci, Dept Clin Mol Informat Med, Nagoya, Aichi, Japan Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina

Oubina, J. R.
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机构:
Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina
Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Estudio Hepatitis Virales, RA-1121 Buenos Aires, DF, Argentina