Genotypes B and C hepatocellular carcinoma-associated hepatitis B virus pre-S mutants: their detection among F1b and A2-but not F4-isolates from Argentina

被引：4

作者：

Trinks, J.

Frias, S. ^{[2
]}

Frider, B. ^{[3
]}

Alessio, A. ^{[3
]}

Pozzati, M. ^{[3
]}

Daleoso, G. ^{[2
]}

Leon, L. ^{[2
]}

Batalla, V. M. ^{[4
]}

Diaz, A. ^{[4
]}

Ameigeiras, B. ^{[2
]}

Oubina, J. R. ^{[1
]}

机构：

[1] Univ Buenos Aires, CONICET, Inst Microbiol & Parasitol Med IMPAM, Fac Med, RA-1121 Buenos Aires, DF, Argentina

[2] Hosp Ramos Mejia, Serv Hepatol, Buenos Aires, DF, Argentina

[3] Hosp Dr Cosme Argerich, Serv Hepatol, Buenos Aires, DF, Argentina

[4] Hosp Pediat Prof Dr Juan P Garrahan, Buenos Aires, DF, Argentina

来源：

JOURNAL OF VIRAL HEPATITIS | 2012年 / 19卷 / 11期

关键词：

Argentina; hepatitis B virus; hepatitis B virus genotypes; hepatocellular carcinoma; pre-S mutants;

D O I：

10.1111/j.1365-2893.2012.01620.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

. Prevalence rates of hepatocellular carcinoma (HCC)-associated hepatitis B virus (HBV) pre-S mutants among most genotypes are still lacking. In this study, viral (sub)genotypes of 70 Argentine nucleotide sequences (33 newly obtained) were determined by phylogenetic analysis, and the presence of such mutants was assessed in the American continent for the first time. Nucleotide substitutions of the pre-S2 start codon were observed in 10% of the HBV/A2 sequences. Ten per cent of the HBV/A2 and 12.5% of the HBV/F1b but none of HBV/F4 exhibited a deletion in the pre-S1/pre-S2 region. The contribution of these variants to liver cirrhosis (LC) and/or HCC development among HBV/F and HBV/A isolates deserves further prospective clinical studies.

引用

页码：823 / 828

页数：6

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