Role of invariant natural killer T cells in lipopolysaccharide-induced pregnancy loss

被引：17

作者：

Li, Liping ^{[1
]}

Shi, Lijuan ^{[2
]}

Yang, Xinying ^{[2
]}

Ren, Lihua ^{[1
]}

Yang, Jing ^{[1
]}

Lin, Yi ^{[3
]}

机构：

[1] Guangzhou Med Univ, Affiliated Guangzhou Peoples Hosp 1, Dept Obstet & Gynecol, Guangzhou 510180, Guangdong, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Obstet & Gynecol, Shanghai 200001, Peoples R China

[3] Shanghai Jiao Tong Univ, Bio X Inst, Shanghai 200240, Peoples R China

来源：

CELLULAR IMMUNOLOGY | 2013年 / 286卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

Inflammation; Invariant natural killer T cells; Lipopolysaccharide; Pregnancy loss; Toll-like receptor; TOLL-LIKE RECEPTORS; NKT CELLS; EXPRESSION; INFLAMMATION; LIGANDS; GLYCOSPHINGOLIPIDS; IMPLANTATION; RECOGNITION; REQUIREMENT; MOLECULES;

D O I：

10.1016/j.cellimm.2013.10.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We aimed to investigate the role of invariant natural killer T (iNICI) cells in infection-associated pregnancy loss. Wild-type (WT) C57BL/6 mice and iNKT cell-deficient J alpha 18(-/-) mice were treated with lipopolysaccharide (LPS). Embryo resorption rates (ERRs), decidual costimulatory molecule and activation molecule expression, and cytokine production were determined. WT and J alpha 18(-/-) mice were adoptively transferred with purified iNKT cells. ERRs, decidual costimulatory molecule and activation molecule expression, and cytokine production were assessed. LPS-treated J alpha 18(-/-) mice showed markedly reduced ERRs, decreased CD40, CD80, CD86, and CD69 expression, and reduced Th1 cytokine production at the maternal-fetal interface compared with WT mice. ERRs, expression of CD40, CD80, CD86, and CD69, and Th1 cytokine production in LPS-injected J alpha 18(-/-) mice following iNKT cell adoptive transfer were remarkably upregulated compared with control mice that did not receive adoptively transferred iNKT cells. Our results suggest that iNKT cells play an important role in LPS-induced pregnancy loss. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：1 / 10

页数：10

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