Regularized pseudo-phase imaging for inspecting and sensing nanoscale features

被引:17
作者
Zhu, Jinlong [1 ]
Zhou, Renjie [2 ]
Zhang, Lenan [3 ]
Ge, Baoliang [3 ,4 ,5 ]
Luo, Chongxin [1 ]
Goddard, Lynford L. [1 ]
机构
[1] Univ Illinois, Dept Elect & Comp Engn, Photon Syst Lab, Urbana, IL 61801 USA
[2] Chinese Univ Hong Kong, Dept Biomed Engn, Shatin, Hong Kong, Peoples R China
[3] MIT, Dept Mech Engn, Cambridge, MA 02139 USA
[4] MIT, Dept Biol Engn, Cambridge, MA 02139 USA
[5] MIT, Laser Biomed Res Ctr, GR Harrison Spect Lab, Cambridge, MA 02139 USA
基金
美国国家卫生研究院;
关键词
OPTICAL COHERENCE TOMOGRAPHY; INTENSITY EQUATION; ANGULAR-MOMENTUM; RETRIEVAL; TRANSPORT; APERTURE;
D O I
10.1364/OE.27.006719
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Recovering tiny nanoscale features using a general optical imaging system is challenging because of poor signal to noise ratio. Rayleigh scattering implies that the detectable signal of an object of size d illuminated by light of wavelength. is proportional to d(6)/lambda(4), which may be several orders of magnitude weaker than that of additive and multiplicative perturbations in the background. In this article, we solve this fundamental issue by introducing the regularized pseudo-phase, an observation quantity for polychromatic visible light microscopy that seems to be more sensitive than conventional intensity images for characterizing nanoscale features. We achieve a significant improvement in signal to noise ratio without making any changes to the imaging hardware. In addition, this framework not only retains the advantages of conventional denoising techniques, but also endows this new measurand (i.e., the pseudo-phase) with an explicit physical meaning analogous to optical phase. Experiments on a NIST reference material 8820 sample demonstrate that we can measure nanoscale defects, minute amounts of tilt in patterned samples, and severely noise-polluted nanostructure profiles with the pseudo-phase framework even when using a low-cost bright-field microscope. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
引用
收藏
页码:6719 / 6733
页数:15
相关论文
共 33 条
  • [1] ORBITAL ANGULAR-MOMENTUM OF LIGHT AND THE TRANSFORMATION OF LAGUERRE-GAUSSIAN LASER MODES
    ALLEN, L
    BEIJERSBERGEN, MW
    SPREEUW, RJC
    WOERDMAN, JP
    [J]. PHYSICAL REVIEW A, 1992, 45 (11): : 8185 - 8189
  • [2] Nondestructive measurement of bond line thickness and die tilt in the die attach for semiconductor packaging
    Chang, Ming
    Deka, Juti Rani
    Tseng, Kai-Ming
    [J]. NONDESTRUCTIVE TESTING AND EVALUATION, 2008, 23 (02) : 89 - 98
  • [3] Patterning of defect arrays with e-beam lithography used to develop a high throughput e-beam defect inspection tool
    Cummings, Kevin D.
    Bunday, Ben
    Malloy, Matt
    Hartley, John
    Banu, Laila
    Mellish, M.
    Chao, Weilun
    Bleier, A. R.
    Banerjee, A.
    [J]. JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B, 2015, 33 (06):
  • [4] Dermatologist-level classification of skin cancer with deep neural networks
    Esteva, Andre
    Kuprel, Brett
    Novoa, Roberto A.
    Ko, Justin
    Swetter, Susan M.
    Blau, Helen M.
    Thrun, Sebastian
    [J]. NATURE, 2017, 542 (7639) : 115 - +
  • [5] Fleischer A, 2014, NAT PHOTONICS, V8, P543, DOI [10.1038/nphoton.2014.108, 10.1038/NPHOTON.2014.108]
  • [6] Optical coherence tomography for ultrahigh resolution in vivo imaging
    Fujimoto, JG
    [J]. NATURE BIOTECHNOLOGY, 2003, 21 (11) : 1361 - 1367
  • [7] Fast automated analysis of strong gravitational lenses with convolutional neural networks
    Hezaveh, Yashar D.
    Levasseur, Laurence Perreault
    Marshall, Philip J.
    [J]. NATURE, 2017, 548 (7669) : 555 - +
  • [8] Coupling of finite elements and boundary elements in electromagnetic scattering
    Hiptmair, R
    [J]. SIAM JOURNAL ON NUMERICAL ANALYSIS, 2003, 41 (03) : 919 - 944
  • [9] Phase retrieval with the transport-of-intensity equation in an arbitrarily shaped aperture by iterative discrete cosine transforms
    Huang, Lei
    Zuo, Chao
    Idir, Mourad
    Qu, Weijuan
    Asundi, Anand
    [J]. OPTICS LETTERS, 2015, 40 (09) : 1976 - 1979
  • [10] A technique for evaluation of CCD video-camera noise
    Irie, Kenji
    McKinnon, Alan E.
    Unsworth, Keith
    Woodhead, Ian M.
    [J]. IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY, 2008, 18 (02) : 280 - 284