The locus of microRNA-10b A critical target for breast cancer insurgence and dissemination

被引:31
作者
Biagioni, Francesca [1 ]
Ben-Moshe, Noa Bossel [2 ]
Fontemaggi, Giulia [1 ]
Yarden, Yosef [3 ]
Domany, Eytan [2 ]
Blandino, Giovanni [1 ]
机构
[1] Regina Elena Italian Natl Canc Inst, Translat Oncogen Unit, Rome, Italy
[2] Weizmann Inst Sci, Dept Phys Complex Syst, IL-76100 Rehovot, Israel
[3] Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, Israel
关键词
microRNA; miR-10b; miR-10b*; cancer; cell proliferation; therapeutic strategies; NUCLEAR EXPORT; CELL-CYCLE; EXPRESSION; DEREGULATION; INVASION; GLIOMA; TUMORS; ANGIOGENESIS; GLIOBLASTOMA; METASTASIS;
D O I
10.4161/cc.25380
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Contemporary microRNA research has led to significant advances in our understanding of the process of tumorigenesis. MicroRNAs participate in different events of a cancer cell's life, through their ability to target hundreds of putative transcripts involved in almost every cellular function, including cell cycle, apoptosis, and differentiation. The relevance of these small molecules is even more evident in light of the emerging linkage between their expression and both prognosis and clinical outcome of many types of human cancers. This identifies microRNAs as potential therapeutic modifiers of cancer phenotypes. From this perspective, we overview here the miR-10b locus and its involvement in cancer, focusing on its role in the establishment (miR-10b*) and spreading (miR-10b) of breast cancer. We conclude that targeting the locus of microRNA 10b holds great potential for cancer treatment.
引用
收藏
页码:2371 / 2375
页数:5
相关论文
共 46 条
[1]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[2]   Context-specific microRNA analysis: identification of functional microRNAs and their mRNA targets [J].
Ben-Moshe, Noa Bossel ;
Avraham, Roi ;
Kedmi, Merav ;
Zeisel, Amit ;
Yitzhaky, Assif ;
Yarden, Yosef ;
Domany, Eytan .
NUCLEIC ACIDS RESEARCH, 2012, 40 (21) :10614-10627
[3]   Functional relevance of miRNA* sequences in human disease [J].
Bhayani, Mihir K. ;
Calin, George A. ;
Lai, Stephen Y. .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2012, 731 (1-2) :14-19
[4]   miR-10b*, a master inhibitor of the cell cycle, is down-regulated in human breast tumours [J].
Biagioni, Francesca ;
Ben-Moshe, Noa Bossel ;
Fontemaggi, Giulia ;
Canu, Valeria ;
Mori, Federica ;
Antoniani, Barbara ;
Di Benedetto, Anna ;
Santoro, Raffaela ;
Germoni, Sabrina ;
De Angelis, Fernanda ;
Cambria, Anna ;
Avraham, Roi ;
Grasso, Giuseppe ;
Strano, Sabrina ;
Muti, Paola ;
Mottolese, Marcella ;
Yarden, Yosef ;
Domany, Eytan ;
Blandino, Giovanni .
EMBO MOLECULAR MEDICINE, 2012, 4 (11) :1214-1229
[5]   Oncogenic miR-181a/b afect the DNA damage response in aggressive breast cancer [J].
Bisso, Andrea ;
Faleschini, Michela ;
Zampa, Federico ;
Capaci, Valeria ;
De Santa, Jacopo ;
Santarpia, Libero ;
Piazza, Silvano ;
Cappelletti, Vera ;
Daidone, Mariagrazia ;
Agami, Reuven ;
Del Sal, Giannino .
CELL CYCLE, 2013, 12 (11) :1679-1687
[6]   MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis [J].
Bloomston, Mark ;
Frankel, Wendy L. ;
Petrocca, Fabio ;
Volinia, Stefano ;
Alder, Hansjuerg ;
Hagan, John P. ;
Liu, Chang-Gong ;
Bhatt, Darshna ;
Taccioli, Cristian ;
Croce, Carlo M. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (17) :1901-1908
[7]   Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].
Calin, GA ;
Dumitru, CD ;
Shimizu, M ;
Bichi, R ;
Zupo, S ;
Noch, E ;
Aldler, H ;
Rattan, S ;
Keating, M ;
Rai, K ;
Rassenti, L ;
Kipps, T ;
Negrini, M ;
Bullrich, F ;
Croce, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529
[8]   MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias [J].
Calin, GA ;
Liu, CG ;
Sevignani, C ;
Ferracin, M ;
Felli, N ;
Dumitru, CD ;
Shimizu, M ;
Cimmino, A ;
Zupo, S ;
Dono, M ;
Dell'Aquila, ML ;
Alder, H ;
Rassenti, L ;
Kipps, TJ ;
Bullrich, F ;
Negrini, M ;
Croce, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11755-11760
[9]   MicroRNAs and cell cycle regulation [J].
Carleton, Michael ;
Cleary, Michele A. ;
Linsley, Peter S. .
CELL CYCLE, 2007, 6 (17) :2127-2132
[10]   Extensive modulation of a set of microRNAs in primary glioblastoma [J].
Ciafrè, SA ;
Galardi, S ;
Mangiola, A ;
Ferracin, M ;
Liu, CG ;
Sabatino, G ;
Negrini, M ;
Maira, G ;
Croce, CM ;
Farace, MG .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 334 (04) :1351-1358