Catalytic enantioselective crossed aldehyde-ketone benzoin cyclization

被引：205
作者：
Takikawa, Hiroshi
Hachisu, Yoshifumi
Bode, Jeffrey W.
Suzuki, Keisuke
机构：
[1] Tokyo Inst Technol, Dept Chem, SORST, JST Agcy,Meguro Ku, Tokyo 1528551, Japan
[2] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 21期
关键词：
asymmetric synthesis; C-C coupling; cyclization; N-heterocyclic carbenes; tertiary alcohols;
D O I：
10.1002/anie.200600268
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Joining together: The catalytic, asymmetric benzoin cyclization of a wide variety ketoaldehydes using chiral triazolium salts of type 1 has been carried out (see scheme). The corresponding cyclized products were prepared in high yields and with excellent enantioselectivities. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：3492 / 3494
页数：3
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