Persistent aggregates in apheresis platelet concentrates are commonly collected from donors with a history of aggregate donation

被引：2

作者：

Feys, H. B. ^{[1
]}

Pottel, H. ^{[2
]}

Coene, J. ^{[3
]}

Vandewalle, G. ^{[3
]}

Vandekerckhove, P. ^{[3
,4
,5
]}

Compernolle, V. ^{[1
,3
,4
]}

机构：

[1] Belgian Red Cross Flanders, Transfus Res Ctr, Ottergemsesteenweg 413, B-9000 Ghent, Belgium

[2] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, KULAK, Kortrijk, Belgium

[3] Belgian Red Cross Flanders, Blood Serv, Mechelen, Belgium

[4] Univ Ghent, Fac Med & Hlth Sci, Ghent, Belgium

[5] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Leuven, Belgium

来源：

VOX SANGUINIS | 2016年 / 111卷 / 04期

关键词：

apheresis; -; donation; Blood collection; Platelet concentrates;

D O I：

10.1111/vox.12437

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelet apheresis sometimes causes persistent aggregates (PA). This study (n = 211) shows that changing the apheresis settings to reach fixed product volumes instead of yields does not influence PA incidence, even though PA products on average contain more platelets than controls. Furthermore, logistic regression was used to model if PA can be predicted on the basis of certain predonation parameters. PA donation history was the only parameter retained, proving a strong determinant of predictability [AUC = 0.735 (SE = 0.022)]. Consequently, donations from a donor with previous PA history are 7.8 times more likely to contain PA than from a donor without preceding history.

引用

页码：431 / 433

页数：3

共 5 条

[1]

Douglas C, 2012, TRANSFUSION, V52, p242A

[2] The contribution of von Willebrand factor-GPIb interactions to persistent aggregate formation in apheresis platelet concentrates [J].

Feys, H. B. ;

Van Aelst, B. ;

Devloo, R. ;

Vandekerckhove, P. ;

Compernolle, V. .

VOX SANGUINIS, 2016, 110 (04) :344-351

[3] Persistent aggregates in apheresis platelet concentrates [J].

Feys, H. B. ;

Coene, J. ;

Devloo, R. ;

Van Aelst, B. ;

Pottel, H. ;

Vandekerckhove, P. ;

Compernolle, V. .

VOX SANGUINIS, 2015, 108 (04) :368-377

[4] Residual aggregates in platelet products: what do we know? [J].

Ringwald, J. ;

Antoon, M. ;

Eckstein, R. ;

Cardoso, M. .

VOX SANGUINIS, 2014, 106 (03) :209-218

[5] Aggregates in platelet concentrates [J].

van der Meer, P. F. ;

Dumont, L. J. ;

Lozano, M. ;

Bondar, N. ;

Wong, J. ;

Ismay, S. ;

Pink, J. ;

Nussbaumer, W. ;

Coene, J. ;

Feys, H. B. ;

Compernolle, V. ;

Devine, D. V. ;

Howe, D. ;

Lin, C. K. ;

Sun, J. ;

Ringwald, J. ;

Strasser, E. F. ;

Eckstein, R. ;

Seltsam, A. ;

Perseghin, P. ;

Proserpio, P. ;

Wakamoto, S. ;

Akino, M. ;

Takamoto, S. ;

Tadokoro, K. ;

Teo, D. ;

Shu, P. H. ;

Chua, S. S. ;

Jimenez-Marco, T. ;

Cid, J. ;

Castro, E. ;

Munoz, I. ;

Gulliksson, H. ;

Sandgren, P. ;

Thomas, S. ;

Petrik, J. ;

McColl, K. ;

Kamel, H. ;

Dugger, J. ;

Sweeney, J. D. ;

Gorlin, J. B. ;

Sutor, L. J. ;

Heath, D. ;

Sayers, M. H. .

VOX SANGUINIS, 2015, 108 (01) :96-125

← 1 →