Pineal teratoma with nephroblastic component in a newborn male: Case report and review of the literature

被引：3

作者：

Thoe, Jessica ^{[1
]}

Ducis, Katrina ^{[2
]}

Eldomery, Mohammad K. ^{[3
]}

Marshall, Mark ^{[4
]}

Ferguson, Michael ^{[1
]}

Vortmeyer, Alexander O. ^{[3
]}

Raskin, Jeffrey S. ^{[2
]}

Coven, Scott L. ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Dept Pediat, Riley Hosp Children, Sect Pediat Hematol Oncol, Indianapolis, IN 46202 USA

[2] Indiana Univ Sch Med, Riley Hosp Children, Dept Neurol Surg, Sect Pediat Neurosurg, Indianapolis, IN 46202 USA

[3] Indiana Univ Sch Med, Dept Pathol, Indianapolis, IN 46202 USA

[4] Indiana Univ Sch Med, Riley Hosp Children, Dept Precis Med, Indianapolis, IN 46202 USA

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2020年 / 80卷

关键词：

Wilm's tumor; Intracranial teratoma; Perinatal tumors; Central nervous system tumors; GERM-CELL TUMORS; EXTRARENAL WILMS-TUMOR; SACROCOCCYGEAL TERATOMA; CHILDHOOD; VARIANT; MUTATIONS; BIOLOGY;

D O I：

10.1016/j.jocn.2020.07.044

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neonatal germ cell tumors are rare and comprise both benign and malignant neoplasms. Teratoma with nephroblastoma is a malignant subset defined pathologically by the presence of nephroblastoma and teratoma elements. Although teratoma with nephroblastoma is most often found in the kidney, 24 of 59 reported cases are associated with extrarenal locations, such as the mediastinum or retroperitoneum. To our knowledge, this is the first patient in the literature with intracranial/pineal teratoma with nephroblastoma, which was managed with staged transcranial approaches resulting in gross total resection and no adjuvant therapy (surveillance observation imaging). We further augmented the patient's management by comprehensive genomic profiling of the tumor to better understand the molecular biology and explore options for targeted therapy. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页码：207 / 214

页数：8

共 81 条

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