Relationship Between Optimism and Outcomes in Patients With Chronic Angina Pectoris

被引:4
作者
Fanaroff, Alexander C. [1 ,2 ]
Prather, Kristi [2 ]
Brucker, Amanda [2 ]
Wojdyla, Daniel [2 ]
Davidson-Ray, Linda [2 ]
Mark, Daniel B. [1 ,2 ]
Williams, Redford B. [3 ,4 ]
Barefoot, John [3 ]
Weisz, Giora [5 ,6 ,7 ]
Ben-Yehuda, Ori [6 ]
Stone, Gregg W. [5 ,6 ]
Ohman, Erik Magnus [1 ,2 ]
Alexander, Karen P. [1 ,2 ]
机构
[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27710 USA
[3] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA
[4] Duke Univ, Med Ctr, Behav Med Res Ctr, Durham, NC USA
[5] Columbia Univ, Div Cardiol, New York, NY USA
[6] Cardiovasc Res Fdn, New York, NY USA
[7] Shaare Zedek Med Ctr, Jerusalem, Israel
关键词
PERCUTANEOUS CORONARY INTERVENTION; INDUCIBLE MYOCARDIAL-ISCHEMIA; QUALITY-OF-LIFE; INCOMPLETE REVASCULARIZATION; RIVER-PCI; RECOVERY EXPECTATIONS; HEART-DISEASE; INFARCTION; RANOLAZINE; MANAGEMENT;
D O I
10.1016/j.amjcard.2019.01.036
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Greater optimism regarding recovery from chronic illness is associated with improved quality of life and clinical outcomes. We performed a post-hoc analysis on the association between optimism and outcomes in Ranolazine in Patients with Incomplete Revascularization after Percutaneous Coronary Intervention (RIVER-PCI), a randomized trial in patients with chronic angina pectoris who had incomplete revascularization following percutaneous coronary intervention. At baseline, patients answered how much they agreed with the phrase, "I am optimistic about my future and returning to a normal lifestyle." We evaluated the association between baseline optimism and time to ischemia-driven hospitalization or revascularization using a Cox model, and the association between baseline optimism and change in frequency of angina pectoris using a mixed measures model. Of 2,389 patients, 782 (33.2%) were very optimistic ("strongly agree"), 1,000 (42.4 %) were optimistic ("agree"), 451 (19.1 %) were neutral ("undecided"), and 123 (5.2%) were not optimistic ("disagree" or "strongly disagree"). Very optimistic patients had a lower prevalence of co-morbidities and less severe angina at baseline than less optimistic patients. The rate of ischemia-driven revascularization or hospitalization was higher in neutral and not optimistic patients compared with very optimistic patients; this finding persisted after adjustment for co-morbidities and baseline angina frequency (hazard ratio 1.42, 95% confidence interval 1.14 to 1.77 for neutral vs very optimistic; hazard ratio 1.38, 95% confidence interval 0.98 to 1.94 for not optimistic vs very optimistic). Neutral and not optimistic patients also had less improvement in angina than very optimistic patients. In conclusion, in patients with angina, those with more self-reported optimism had better health status outcomes. Whether structured interventions targeting optimism improve outcomes in these patients warrants further study. (C) 2019 Elsevier Inc. All rights reserved.
引用
收藏
页码:1399 / 1405
页数:7
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