SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1,3-BENZOTHIAZOLYL OXADIAZOLE DERIVATIVES

被引：0
|
作者：
Rajeeva, B. [1 ]
Kumar, Vishal [2 ]
Shantakumar, S. M. [1 ]
机构：
[1] VL Coll Pharm, Dept Pharmaceut Chem, Raichur 584103, India
[2] Vivek Coll Tech Educ, Bijnor 246701, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2013年 / 22卷 / 04期
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D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new series of 2-[(4'-acetyl-5'-aryl)-1',3',4'-oxadiazole]-1,3-benzothiazole (6a(1)-6a(6)) were synthesized from arylmethylidenp-1,3-benzothiazole-2-carbohydrazides (5a(1)-5a(6)) in good yields. The structures of the newly synthesized compounds have been confirmed by IR, H-1 NMR and Mass spectral analysis. All the synthesized compounds were screened for their antibacterial, anti-inflammatory and analgesic activity. Among the synthesized compounds 6a(2) and 6a(4) exhibited a broad spectrum antibacterial activity. Compounds (6a(1)-6a(6)) exhibited highly significant anti-inflammatory activity at 3rd and 4th hr whereas the tested compounds exhibited highly significant analgesic activity at 90 and 120 minutes.
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页码：357 / 362
页数：6
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