CD1d-lipid antigen recognition by the γδ TCR

被引：237

作者：

Uldrich, Adam P. ^{[1
]}

Le Nours, Jerome ^{[2
,3
]}

Pellicci, Daniel G. ^{[1
]}

Gherardin, Nicholas A. ^{[1
]}

McPherson, Kirsty G. ^{[1
]}

Lim, Ricky T. ^{[1
]}

Patel, Onisha ^{[2
]}

Beddoe, Travis ^{[2
]}

Gras, Stephanie ^{[2
]}

Rossjohn, Jamie ^{[2
,3
,4
]}

Godfrey, Dale I. ^{[1
]}

机构：

[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia

[2] Monash Univ, Sch Biomed Sci, Dept Biochem & Mol Biol, Clayton, Vic, Australia

[3] Monash Univ, Australian Res Council, Ctr Excellence Struct & Funct Microbial Genom, Clayton, Vic, Australia

[4] Cardiff Univ, Sch Med, Inst Infect & Immun, Cardiff CF10 3AX, S Glam, Wales

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 11期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会; 澳大利亚研究理事会;

关键词：

T-CELL-RECEPTOR; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; CD1D; REACTIVITY; COMPLEXES; SELECTION; FEATURES; BINDING; INNATE;

D O I：

10.1038/ni.2713

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The T cell repertoire comprises alpha beta and gamma delta T cell lineages. Although it is established how alpha beta T cell antigen receptors (TCRs) interact with antigen presented by antigen-presenting molecules, this is unknown for gamma delta TCRs. We describe a population of human V(delta)1(+) gamma delta T cells that exhibit autoreactivity to CD1d and provide a molecular basis for how a gamma delta TCR binds CD1d-alpha-galactosylceramide (alpha-GalCer). The gamma delta TCR docked orthogonally, over the A' pocket of CD1d, in which the V(delta)1-chain, and in particular the germ line-encoded CDR1 delta loop, dominated interactions with CD1d. The TCR gamma-chain sat peripherally to the interface, with the CDR3 gamma loop representing the principal determinant for alpha-GalCer specificity. Accordingly, we provide insight into how a gamma delta TCR binds specifically to a lipid-loaded antigen-presenting molecule.

引用

页码：1137 / U125

页数：11

共 49 条

[31] Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers [J].

Matsuda, JL ;

Naidenko, OV ;

Gapin, L ;

Nakayama, T ;

Taniguchi, M ;

Wang, CR ;

Koezuka, Y ;

Kronenberg, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (05) :741-753

[32] Innate-Like Control of Human iNKT Cell Autoreactivity via the Hypervariable CDR3β Loop [J].

Matulis, Gediminas ;

Sanderson, Joseph P. ;

Lissin, Nikolai M. ;

Asparuhova, Maria B. ;

Bommineni, Gopal R. ;

Schuemperli, Daniel ;

Schmidt, Richard R. ;

Villiger, Peter M. ;

Jakobsen, Bent K. ;

Gadola, Stephan D. .

PLOS BIOLOGY, 2010, 8 (06)

[33] Solving structures of protein complexes by molecular replacement with Phaser [J].

McCoy, Airlie J. .

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2007, 63 :32-41

[34] CEREBROSPINAL-FLUID OF MULTIPLE-SCLEROSIS PATIENTS - MOLECULAR AND FUNCTIONAL ANALYSES OF T-CELL RECEPTOR-GAMMA-DELTA REPERTOIRE IS SKEWED IN ANTIGEN-REACTIVE GAMMA-DELTA CLONES [J].

NICK, S ;

PILERI, P ;

TONGIANI, S ;

UEMATSU, Y ;

KAPPOS, L ;

DELIBERO, G .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (02) :355-363

[35] Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor [J].

Patel, Onisha ;

Pellicci, Daniel G. ;

Gras, Stephanie ;

Sandoval-Romero, Maria L. ;

Uldrich, Adam P. ;

Mallevaey, Thierry ;

Clarke, Andrew J. ;

Le Nours, Jerome ;

Theodossis, Alex ;

Cardell, Susanna L. ;

Gapin, Laurent ;

Godfrey, Dale I. ;

Rossjohn, Jamie .

NATURE IMMUNOLOGY, 2012, 13 (09) :857-863

[36] Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors [J].

Pellicci, Daniel G. ;

Clarke, Andrew J. ;

Patel, Onisha ;

Mallevaey, Thierry ;

Beddoe, Travis ;

Le Nours, Jerome ;

Uldrich, Adam P. ;

McCluskey, James ;

Besra, Gurdyal S. ;

Porcelli, Steven A. ;

Gapin, Laurent ;

Godfrey, Dale I. ;

Rossjohn, Jamie .

NATURE IMMUNOLOGY, 2011, 12 (09) :827-U3

[37] Recognition of CD1d-restricted antigens by natural killer T cells [J].

Rossjohn, Jamie ;

Pellicci, Daniel G. ;

Patel, Onisha ;

Gapin, Laurent ;

Godfrey, Dale I. .

NATURE REVIEWS IMMUNOLOGY, 2012, 12 (12) :845-857

[38] CD1-restricted recognition of exogenous and self-lipid antigens by duodenal γδ plus T lymphocytes [J].

Russano, Anna M. ;

Bassotti, Gabrio ;

Agea, Elisabetta ;

Bistoni, Onelia ;

Mazzocchi, Alessandro ;

Morelli, Antonio ;

Porcelli, Steven A. ;

Spinozzi, Fabrizio .

JOURNAL OF IMMUNOLOGY, 2007, 178 (06) :3620-3626

[39] Recognition of pollen-derived phosphatidylethanolamine by human CD1d-restricted γδ T cells [J].

Russano, Anna M. ;

Agea, Elisabetta ;

Corazzi, Lanfranco ;

Postle, Antyony D. ;

De Libero, Gennaro ;

Porcelli, Steven ;

de Benedictis, Fernando M. ;

Spinozzi, Fabrizio .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (05) :1178-1184

[40] THE NATURE OF MAJOR HISTOCOMPATIBILITY COMPLEX RECOGNITION BY GAMMA-DELTA-T-CELLS [J].

SCHILD, H ;

MAVADDAT, N ;

LITZENBERGER, C ;

EHRICH, EW ;

DAVIS, MM ;

BLUESTONE, JA ;

MATIS, L ;

DRAPER, RK ;

CHIEN, YH .

CELL, 1994, 76 (01) :29-37

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