CD1d-lipid antigen recognition by the γδ TCR

被引：237

作者：

Uldrich, Adam P. ^{[1
]}

Le Nours, Jerome ^{[2
,3
]}

Pellicci, Daniel G. ^{[1
]}

Gherardin, Nicholas A. ^{[1
]}

McPherson, Kirsty G. ^{[1
]}

Lim, Ricky T. ^{[1
]}

Patel, Onisha ^{[2
]}

Beddoe, Travis ^{[2
]}

Gras, Stephanie ^{[2
]}

Rossjohn, Jamie ^{[2
,3
,4
]}

Godfrey, Dale I. ^{[1
]}

机构：

[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia

[2] Monash Univ, Sch Biomed Sci, Dept Biochem & Mol Biol, Clayton, Vic, Australia

[3] Monash Univ, Australian Res Council, Ctr Excellence Struct & Funct Microbial Genom, Clayton, Vic, Australia

[4] Cardiff Univ, Sch Med, Inst Infect & Immun, Cardiff CF10 3AX, S Glam, Wales

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 11期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会; 澳大利亚研究理事会;

关键词：

T-CELL-RECEPTOR; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; CD1D; REACTIVITY; COMPLEXES; SELECTION; FEATURES; BINDING; INNATE;

D O I：

10.1038/ni.2713

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The T cell repertoire comprises alpha beta and gamma delta T cell lineages. Although it is established how alpha beta T cell antigen receptors (TCRs) interact with antigen presented by antigen-presenting molecules, this is unknown for gamma delta TCRs. We describe a population of human V(delta)1(+) gamma delta T cells that exhibit autoreactivity to CD1d and provide a molecular basis for how a gamma delta TCR binds CD1d-alpha-galactosylceramide (alpha-GalCer). The gamma delta TCR docked orthogonally, over the A' pocket of CD1d, in which the V(delta)1-chain, and in particular the germ line-encoded CDR1 delta loop, dominated interactions with CD1d. The TCR gamma-chain sat peripherally to the interface, with the CDR3 gamma loop representing the principal determinant for alpha-GalCer specificity. Accordingly, we provide insight into how a gamma delta TCR binds specifically to a lipid-loaded antigen-presenting molecule.

引用

页码：1137 / U125

页数：11

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