Androgen receptor distribution in the social decision-making network of eusocial naked mole-rats

被引：7
作者：
Holmes, Melissa M. [1 ,2 ]
Van Mil, Spencer [1 ]
Bulkowski, Camila [1 ]
Goldman, Sharry L. [3 ]
Goldman, Bruce D. [3 ]
Forger, Nancy G. [4 ]
机构：
[1] Univ Toronto, Dept Psychol, Mississauga, ON L5L 1C6, Canada
[2] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M5S 3G5, Canada
[3] Univ Connecticut, Dept Ecol & Evolutionary Biol, Storrs, CT 06269 USA
[4] Georgia State Univ, Inst Neurosci, Atlanta, GA 30302 USA
来源：
BEHAVIOURAL BRAIN RESEARCH | 2013年 / 256卷
基金：
美国国家科学基金会; 加拿大自然科学与工程研究理事会;
关键词：
Androgen receptor; Anterior hypothalamus; Lateral septum; Naked mole-rat; Preoptic area; Social status; BEHAVIOR NETWORK; MESSENGER-RNA; BRAIN; IMMUNOREACTIVITY; AMYGDALA; STRESS; INTACT; CELLS;
D O I：
10.1016/j.bbr.2013.08.025
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Naked mole-rats are highly social rodents that live in large groups and exhibit a strict reproductive and social hierarchy. Only a few animals in each colony breed; the remainder are non-reproductive and are socially subordinate to breeders. We have examined androgen receptor immunoreactive (AR+) cells in brain regions comprising the recently described social decision-making network in subordinate and breeder naked mole-rats of both sexes. We find that subordinates have a significantly higher percentage of AR+ cells in all brain regions expressing this protein. By contrast, there were no significant effects of sex and no sex-by-status interactions on the percentage of AR+ cells. Taken together with previous findings, the present data complete a systematic assessment of the distribution of AR protein in the social decision-making network of the eusocial mammalian brain and demonstrate a significant role for social status in the regulation of this protein throughout many nodes of this network. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：214 / 218
页数：5
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