Antiviral Activity of SIO2-Polyphenol Composites Prepared Mechanochemically from Plant Raw Materials

被引：5

作者：

Shapolova, E. G. ^{[1
]}

Lomovskii, O. I. ^{[1
]}

Kazachinskaya, E. I. ^{[2
,4
]}

Loktev, V. B. ^{[2
,3
,4
]}

Teplyakova, T. V. ^{[2
]}

机构：

[1] Russian Acad Sci, Inst Solid State Chem & Mechanochem, Siberian Branch, 18 Kutateladze St, Novosibirsk 630128, Russia

[2] VECTOR State Res Ctr Virol & Biotechnol, Koltsov 630559, Novosibirsk Reg, Russia

[3] Russian Acad Sci, Akad Lavrenteva Prosp, Inst Cytol & Genet, Siberian Branch, 10 Akad Lavrenteva Prosp, Novosibirsk 630090, Russia

[4] Novosibirsk Natl Res State Univ, 2 Pirogova St, Novosibirsk 630090, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 50卷 / 09期

关键词：

SiO2-polyphenol composites; dihydroquercetin; pyrocatechol; antiviral activity with respect to HSV-2; WNV; DRUG-DELIVERY; FLAVONOIDS;

D O I：

10.1007/s11094-016-1497-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Composites of SiO2 and polyphenols from plant raw materials and model composites based on amorphous SiO2 and dihydroquercetin and pyrocatechol were prepared by solid-state mechanochemistry. Results for the antiviral activities of these composites with respect to herpes simplex virus type 2 (HSV-2) and West Nile virus are presented and compared with those of several chemotherapeutics and chaga (Inonotus obliquus) extract.

引用

页码：595 / 599

页数：5