Antiviral Activity of SIO2-Polyphenol Composites Prepared Mechanochemically from Plant Raw Materials

被引：5
|
作者：
Shapolova, E. G. [1 ]
Lomovskii, O. I. [1 ]
Kazachinskaya, E. I. [2 ,4 ]
Loktev, V. B. [2 ,3 ,4 ]
Teplyakova, T. V. [2 ]
机构：
[1] Russian Acad Sci, Inst Solid State Chem & Mechanochem, Siberian Branch, 18 Kutateladze St, Novosibirsk 630128, Russia
[2] VECTOR State Res Ctr Virol & Biotechnol, Koltsov 630559, Novosibirsk Reg, Russia
[3] Russian Acad Sci, Akad Lavrenteva Prosp, Inst Cytol & Genet, Siberian Branch, 10 Akad Lavrenteva Prosp, Novosibirsk 630090, Russia
[4] Novosibirsk Natl Res State Univ, 2 Pirogova St, Novosibirsk 630090, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 50卷 / 09期
关键词：
SiO2-polyphenol composites; dihydroquercetin; pyrocatechol; antiviral activity with respect to HSV-2; WNV; DRUG-DELIVERY; FLAVONOIDS;
D O I：
10.1007/s11094-016-1497-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Composites of SiO2 and polyphenols from plant raw materials and model composites based on amorphous SiO2 and dihydroquercetin and pyrocatechol were prepared by solid-state mechanochemistry. Results for the antiviral activities of these composites with respect to herpes simplex virus type 2 (HSV-2) and West Nile virus are presented and compared with those of several chemotherapeutics and chaga (Inonotus obliquus) extract.
引用
收藏
页码：595 / 599
页数：5
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