ANTIMICROBIAL ACTIVITY OF CERAMIC DISKS LOADED WITH SILVER IONS AND NITROXOLINE

被引：0

作者：

Danistean, Ancuta ^{[1
]}

Gorea, Maria ^{[1
]}

Avram, Alexandra ^{[1
]}

Rapuntean, Sorin ^{[2
]}

Tomoaia, Gheorghe ^{[3
]}

Mocanu, Aurora ^{[1
]}

Garbo, Corina ^{[1
]}

Horovitz, Ossi ^{[1
]}

Tomoaia-Cotisel, Maria ^{[1
]}

机构：

[1] Univ Babes Bolyai, Fac Chem & Chem Engn, 11 Arany Janos Str, RO-400028 Cluj Napoca, Romania

[2] Univ Agr Sci & Vet Med Cluj Napoca, 3-5 Manastur Str, RO-400372 Cluj Napoca, Romania

[3] Iuliu Hatieganu Univ Med & Pharm, Orthopedy & Traumatol Dept, 47 Traian Mosoiu Str, RO-400132 Cluj Napoca, Romania

来源：

STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA | 2016年 / 61卷 / 03期

关键词：

ceramics; hydroxyapatite; silver ions; 5-nitro-8-hydroxyquinoline; antimicrobial effect; ANTIBACTERIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; NANOSTRUCTURED PHOSPHATES; NANOPARTICLES; 5-NITRO-8-HYDROXYQUINOLINE; HYDROXYAPATITE; COLLAGEN;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ceramic porous disks made of hydroxyapatite, HAP, loaded with silver ions and nitroxoline (5-nitro-8-hydroxyquinoline, NHQ) are used in vitro against pathogens, such as Staphylococcus aureus. HAP powder was synthesized by a wet chemical method, and its phase purity and nanocrystalline structure were assessed by X-ray diffraction (XRD), transmission electron microscopy (TEM) and atomic force microscopy (AFM). Disk samples of HAP were prepared and impregnated with Ag+ ions and NHQ solutions. A strong antimicrobial activity of all samples was assessed by the diffusion assay in vitro against Staphylococcus aureus. Through the development of the optimal composition of these biomaterials, this approach might hold potential applications for antimicrobial coating, bone tissue engineering scaffolds and biomedical devices.

引用

页码：275 / 283

页数：9

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