A protein-polymer hybrid gene carrier based on thermophilic histone and polyethylenimine

被引：5
作者：
Shi, Hui [1 ]
Han, Haobo [1 ]
Xing, Zhen [1 ]
Chen, Jiawen [1 ]
Wang, Yudi [1 ]
Zhang, Aijun [1 ]
Shi, Wei [1 ]
Li, Quanshun [1 ]
机构：
[1] Jilin Univ, Key Lab Mol Enzymol & Engn, Minist Educ, Sch Life Sci, Changchun 130012, Peoples R China
来源：
NEW JOURNAL OF CHEMISTRY | 2015年 / 39卷 / 09期
关键词：
IN-VITRO; DELIVERY; DNA; VECTOR; TRANSFECTION; COMPLEX; CELLS; VIVO; H3; HU;
D O I：
10.1039/c5nj01272d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A protein-polymer hybrid gene carrier HEP was successfully constructed based on thermophilic histone and polyethylenimine. The carrier exhibited low cytotoxicity and a high transfection efficiency due to the synergistic effects between the two components, which makes it a potential vehicle in tumor gene therapy.
引用
收藏
页码：6718 / 6721
页数：4
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