DNA methylation in ductal carcinoma in situ of the breast

被引：18

作者：

Pang, Jia-Min B. ^{[1
,2
]}

Dobrovic, Alexander ^{[1
,3
]}

Fox, Stephen B. ^{[1
,3
]}

机构：

[1] Peter MacCallum Canc Ctr, Dept Pathol, East Melbourne, Vic 3002, Australia

[2] Univ Melbourne, Dept Pathol, Melbourne, Vic 3002, Australia

[3] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3010, Australia

来源：

BREAST CANCER RESEARCH | 2013年 / 15卷 / 03期

关键词：

SURGICAL ADJUVANT BREAST; CPG ISLAND METHYLATION; GENOME-WIDE ANALYSIS; PROMOTER HYPERMETHYLATION; HIGH-THROUGHPUT; BIOLOGICAL MARKERS; LOCAL RECURRENCE; EARLY EVENT; ABERRANT METHYLATION; CANCER;

D O I：

10.1186/bcr3420

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ductal carcinoma in situ (DCIS) is a non-obligate precursor lesion of invasive carcinoma of the breast. Current prognostic markers based on histopathological examination are unable to accurately predict which DCIS cases will progress to invasive carcinoma or recur after surgical excision. Epigenetic changes have been shown to be a significant driver of tumorigenesis, and DNA methylation of specific gene promoters provides predictive and prognostic markers in many types of cancer, including invasive breast cancer. In general, the spectrum of genes that are methylated in DCIS strongly resembles that seen in invasive ductal carcinoma. The identification of specific prognostic markers in DCIS remains elusive and awaits additional work investigating a large panel of methylatable genes by using sensitive and reproducible technologies. This review critically appraises the role of methylation in DCIS and its use as a biomarker.

引用

页数：11

共 101 条

[1] Silencing of tumor suppressor genes RASSF1A, SLIT2, and WIF1 by promoter hypermethylation in hereditary breast cancer [J].

Alvarez, Carolina ;

Tapia, Teresa ;

Cornejo, Valeria ;

Fernandez, Wanda ;

Munoz, Alex ;

Camus, Mauricio ;

Alvarez, Manuel ;

Devoto, Luigi ;

Carvallo, Pilar .

MOLECULAR CARCINOGENESIS, 2013, 52 (06) :475-487

[2] Molecular Grading of Ductal Carcinoma In situ of the Breast [J].

Balleine, Rosemary L. ;

Webster, Lucy R. ;

Davis, Sean ;

Salisbury, Elizabeth L. ;

Palazzo, Juan P. ;

Schwartz, Gordon F. ;

Cornfield, Dennis B. ;

Walker, Robert L. ;

Byth, Karen ;

Clarke, Christine L. ;

Meltzer, Paul S. .

CLINICAL CANCER RESEARCH, 2008, 14 (24) :8244-8252

[3]

Bianco T, 1999, HUM MUTAT, V14, P289, DOI 10.1002/(SICI)1098-1004(199910)14:4<289::AID-HUMU3>3.0.CO

[4]

2-A

[5] Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: Ten-Year results of European Organisation for Research and Treatment of Cancer randomized phase III trial 10853 - A study by the EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group [J].

Bijker, Nina ;

Meijnen, Philip ;

Peterse, Johannes L. ;

Bogaerts, Jan ;

Van Hoorebeeck, Irene ;

Julien, Jean-Pierre ;

Gennaro, Massimiliano ;

Rouanet, Philippe ;

Avril, Antoine ;

Fentiman, Ian S. ;

Bartelink, Harry ;

Rutgers, Emiel J. Th. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (21) :3381-3387

[6] Detection of MGMT Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 MGMT Promoter Single Nucleotide Polymorphism [J].

Candiloro, Ida L. M. ;

Dobrovic, Alexander .

CANCER PREVENTION RESEARCH, 2009, 2 (10) :862-867

[7] Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the CDKN2B (p15) gene [J].

Candiloro, Ida L. M. ;

Mikeska, Thomas ;

Hokland, Peter ;

Dobrovic, Alexander .

EPIGENETICS & CHROMATIN, 2008, 1 (1)

[8] Genome-wide DNA methylation profiling of non-small cell lung carcinomas [J].

Carvalho, Rejane Hughes ;

Haberle, Vanja ;

Hou, Jun ;

van Gent, Teus ;

Thongjuea, Supat ;

van IJcken, Wilfred ;

Kockx, Christel ;

Brouwer, Rutger ;

Rijkers, Erikjan ;

Sieuwerts, Anieta ;

Foekens, John ;

van Vroonhoven, Mirjam ;

Aerts, Joachim ;

Grosveld, Frank ;

Lenhard, Boris ;

Philipsen, Sjaak .

EPIGENETICS & CHROMATIN, 2012, 5

[9] Prognostic significance of gene-specific promoter hypermethylation in breast cancer patients [J].

Cho, Yoon Hee ;

Shen, Jing ;

Gammon, Marilie D. ;

Zhang, Yu-Jing ;

Wang, Qiao ;

Gonzalez, Karina ;

Xu, Xinran ;

Bradshaw, Patrick T. ;

Teitelbaum, Susan L. ;

Garbowski, Gail ;

Hibshoosh, Hanina ;

Neugut, Alfred I. ;

Chen, Jia ;

Santella, Regina M. .

BREAST CANCER RESEARCH AND TREATMENT, 2012, 131 (01) :197-205

[10]

CLARK SJ, 1994, NUCLEIC ACIDS RES, V22, P2990, DOI 10.1093/nar/22.15.2990

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